{ "cells": [ { "cell_type": "markdown", "id": "927a8847", "metadata": {}, "source": [ "# Analyze Contributions of different methods to Annotation\n", "\n", "This notebook analyzes relative contributions of different IEA methods to annotation" ] }, { "cell_type": "code", "id": "3ae3cf2d", "metadata": { "ExecuteTime": { "end_time": "2024-12-11T16:02:04.540490Z", "start_time": "2024-12-11T16:02:04.504779Z" } }, "source": [ "from oaklib import get_adapter\n", "from oaklib.datamodels.vocabulary import IS_A, PART_OF\n", "from oaklib.datamodels.association import Association\n", "from oaklib.parsers.gaf_association_parser import GafAssociationColumns\n", "from oaklib.utilities.associations.association_differ import AssociationDiffer\n", "from oaklib.utilities.subsets.slimmer_utils import filter_redundant\n", "import pandas as pd\n", "\n", "# Get a GO handle\n", "go = get_adapter(\"sqlite:obo:go\")" ], "outputs": [], "execution_count": 2 }, { "cell_type": "code", "id": "9864c7c1", "metadata": { "ExecuteTime": { "end_time": "2024-12-11T16:02:08.111905Z", "start_time": "2024-12-11T16:02:08.108846Z" } }, "source": [ "# Data Dictionary\n", "GENE = GafAssociationColumns.local_id.value\n", "TERM = GafAssociationColumns.ontology_class_ref.value" ], "outputs": [], "execution_count": 3 }, { "cell_type": "code", "id": "ebce273b", "metadata": { "ExecuteTime": { "end_time": "2024-12-11T16:02:08.666300Z", "start_time": "2024-12-11T16:02:08.661808Z" } }, "source": [ "# Cache HTTP requests\n", "import requests_cache\n", "requests_cache.install_cache(\"output/requests_cache\")" ], "outputs": [], "execution_count": 4 }, { "cell_type": "code", "id": "fac3d6c9", "metadata": { "ExecuteTime": { "end_time": "2024-12-11T16:02:09.401204Z", "start_time": "2024-12-11T16:02:09.398604Z" } }, "source": [ "# Alias for GO command line queries" ], "outputs": [], "execution_count": 5 }, { "cell_type": "code", "id": "35dad912", "metadata": { "ExecuteTime": { "end_time": "2024-12-11T16:02:10.246939Z", "start_time": "2024-12-11T16:02:10.243546Z" } }, "source": [ "%alias go runoak -i sqlite:obo:go" ], "outputs": [], "execution_count": 6 }, { "cell_type": "markdown", "id": "8c0d433d", "metadata": {}, "source": [ "## Routine to parse a GAF to a DataFrame" ] }, { "cell_type": "code", "id": "3c68178f", "metadata": { "ExecuteTime": { "end_time": "2024-12-11T16:02:52.535244Z", "start_time": "2024-12-11T16:02:52.496886Z" } }, "source": [ "def gaf2df(path: str) -> pd.DataFrame:\n", " df = pd.read_csv(path, sep=\"\\t\", comment=\"!\", names=[c.value for c in GafAssociationColumns])\n", " return df.query(f\"'|' not in qualifiers\")\n", "\n", "df = gaf2df(\"../../../../tests/input/mgi-truncated.gaf\") \n", "df" ], "outputs": [ { "data": { "text/plain": [ " db local_id db_object_symbol qualifiers ontology_class_ref \\\n", "0 MGI MGI:1918911 0610005C13Rik enables GO:0003674 \n", "1 MGI MGI:1918911 0610005C13Rik is_active_in GO:0005575 \n", "2 MGI MGI:1918911 0610005C13Rik involved_in GO:0008150 \n", "3 MGI MGI:1923503 0610006L08Rik enables GO:0003674 \n", "4 MGI MGI:1923503 0610006L08Rik is_active_in GO:0005575 \n", "5 MGI MGI:1923503 0610006L08Rik involved_in GO:0008150 \n", "6 MGI MGI:1925547 0610008J02Rik enables GO:0003674 \n", "7 MGI MGI:1925547 0610008J02Rik is_active_in GO:0005575 \n", "8 MGI MGI:1925547 0610008J02Rik involved_in GO:0008150 \n", "9 MGI MGI:1913300 0610009B22Rik involved_in GO:0001501 \n", "10 MGI MGI:1913300 0610009B22Rik located_in GO:0005634 \n", "11 MGI MGI:1913300 0610009B22Rik located_in GO:0005654 \n", "12 MGI MGI:1913300 0610009B22Rik located_in GO:0005783 \n", "13 MGI MGI:1913300 0610009B22Rik part_of GO:0030008 \n", "14 MGI MGI:1913300 0610009B22Rik located_in GO:0043231 \n", "15 MGI MGI:1913300 0610009B22Rik enables GO:0044325 \n", "16 MGI MGI:1913300 0610009B22Rik located_in GO:0048471 \n", "17 MGI MGI:3698435 0610009E02Rik enables GO:0003674 \n", "18 MGI MGI:3698435 0610009E02Rik is_active_in GO:0005575 \n", "\n", " supporting_references evidence_type with_or_from aspect \\\n", "0 MGI:MGI:2156816|GO_REF:0000015 ND NaN F \n", "1 MGI:MGI:2156816|GO_REF:0000015 ND NaN C \n", "2 MGI:MGI:2156816|GO_REF:0000015 ND NaN P \n", "3 MGI:MGI:2156816|GO_REF:0000015 ND NaN F \n", "4 MGI:MGI:2156816|GO_REF:0000015 ND NaN C \n", "5 MGI:MGI:2156816|GO_REF:0000015 ND NaN P \n", "6 MGI:MGI:2156816|GO_REF:0000015 ND NaN F \n", "7 MGI:MGI:2156816|GO_REF:0000015 ND NaN C \n", "8 MGI:MGI:2156816|GO_REF:0000015 ND NaN P \n", "9 MGI:MGI:4834177|GO_REF:0000096 ISO UniProtKB:P0DI81 P \n", "10 MGI:MGI:4834177|GO_REF:0000096 ISO UniProtKB:P0DI81 C \n", "11 MGI:MGI:4834177|GO_REF:0000096 ISO UniProtKB:P0DI81 C \n", "12 MGI:MGI:4834177|GO_REF:0000096 ISO UniProtKB:P0DI81 C \n", "13 MGI:MGI:4834177|GO_REF:0000096 ISO UniProtKB:P0DI81 C \n", "14 MGI:MGI:4834177|GO_REF:0000096 ISO UniProtKB:P0DI81 C \n", "15 MGI:MGI:4834177|GO_REF:0000096 ISO UniProtKB:P0DI81 F \n", "16 MGI:MGI:4834177|GO_REF:0000096 ISO UniProtKB:P0DI81 C \n", "17 MGI:MGI:2156816|GO_REF:0000015 ND NaN F \n", "18 MGI:MGI:2156816|GO_REF:0000015 ND NaN C \n", "\n", " db_object_name db_object_synonyms db_object_type \\\n", "0 RIKEN cDNA 0610005C13 gene NaN gene \n", "1 RIKEN cDNA 0610005C13 gene NaN gene \n", "2 RIKEN cDNA 0610005C13 gene NaN gene \n", "3 RIKEN cDNA 0610006L08 gene NaN gene \n", "4 RIKEN cDNA 0610006L08 gene NaN gene \n", "5 RIKEN cDNA 0610006L08 gene NaN gene \n", "6 RIKEN cDNA 0610008J02 gene NaN gene \n", "7 RIKEN cDNA 0610008J02 gene NaN gene \n", "8 RIKEN cDNA 0610008J02 gene NaN gene \n", "9 RIKEN cDNA 0610009B22 gene NaN protein \n", "10 RIKEN cDNA 0610009B22 gene NaN protein \n", "11 RIKEN cDNA 0610009B22 gene NaN protein \n", "12 RIKEN cDNA 0610009B22 gene NaN protein \n", "13 RIKEN cDNA 0610009B22 gene NaN protein \n", "14 RIKEN cDNA 0610009B22 gene NaN protein \n", "15 RIKEN cDNA 0610009B22 gene NaN protein \n", "16 RIKEN cDNA 0610009B22 gene NaN protein \n", "17 RIKEN cDNA 0610009E02 gene NaN gene \n", "18 RIKEN cDNA 0610009E02 gene NaN gene \n", "\n", " db_object_taxon annotation_date assigned_by annotation_extensions \\\n", "0 taxon:10090 20200917 MGI NaN \n", "1 taxon:10090 20100209 MGI NaN \n", "2 taxon:10090 20100209 MGI NaN \n", "3 taxon:10090 20120430 MGI NaN \n", "4 taxon:10090 20120430 MGI NaN \n", "5 taxon:10090 20120430 MGI NaN \n", "6 taxon:10090 20210426 MGI NaN \n", "7 taxon:10090 20210426 MGI NaN \n", "8 taxon:10090 20210426 MGI NaN \n", "9 taxon:10090 20110927 MGI NaN \n", "10 taxon:10090 20160909 MGI NaN \n", "11 taxon:10090 20151016 MGI NaN \n", "12 taxon:10090 20151016 MGI NaN \n", "13 taxon:10090 20170627 MGI NaN \n", "14 taxon:10090 20151016 MGI NaN \n", "15 taxon:10090 20130215 MGI NaN \n", "16 taxon:10090 20130215 MGI NaN \n", "17 taxon:10090 20100209 MGI NaN \n", "18 taxon:10090 20100209 MGI NaN \n", "\n", " gene_product_form \n", "0 NaN \n", "1 NaN \n", "2 NaN \n", "3 NaN \n", "4 NaN \n", "5 NaN \n", "6 NaN \n", "7 NaN \n", "8 NaN \n", "9 NaN \n", "10 NaN \n", "11 NaN \n", 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" ], "text/plain": [ " 0\n", "0 local_id\n", "1 unique1\n", "2 unique2\n", "3 local_id\n", "4 unique1\n", "5 unique2\n", "6 local_id\n", "7 unique1\n", "8 unique2\n", "9 local_id\n", "10 unique1\n", "11 unique2\n", "12 local_id\n", "13 unique1\n", "14 unique2" ] }, "execution_count": 14, "metadata": {}, "output_type": "execute_result" } ], "source": [ "\n", "COMMON = \"common\"\n", "UNIQUE1 = \"unique1\"\n", "UNIQUE2 = \"unique2\"\n", "\n", "def old_compare_gene_dfs(gene, df1, df2, preds=None):\n", " terms1 = set(df1[TERM])\n", " terms2 = set(df2[TERM])\n", " closure1 = set(list(go.ancestors(list(terms1), preds)))\n", " closure2 = set(list(go.ancestors(list(terms2), preds)))\n", " nr_closure1 = set(filter_redundant(go, closure1, preds))\n", " nr_closure2 = set(filter_redundant(go, closure2, preds))\n", " unique1 = nr_closure1.difference(nr_closure2)\n", " unique2 = nr_closure2.difference(nr_closure1)\n", " return {GENE: gene, UNIQUE1: unique1, UNIQUE2: unique2}\n", "\n", "def old_compare_gaf_dfs(df1, df2, preds=[IS_A, PART_OF]):\n", " genes1 = set(df1[GENE])\n", " genes2 = set(df2[GENE])\n", " objs = []\n", " for gene in genes1.union(genes2):\n", " subdf1 = df1.query(f\"{GENE} == '{gene}'\")\n", " subdf2 = df2.query(f\"{GENE} == '{gene}'\")\n", " for obj in compare_gene_dfs(gene, subdf1, subdf2, preds):\n", " objs.append(obj)\n", " return pd.DataFrame(objs)\n", "\n", "compare_gaf_dfs(df1, df2, preds=[IS_A, PART_OF])" ] }, { "cell_type": "markdown", "id": "4fefddc4", "metadata": {}, "source": [ "## Function to analyze contribution" ] }, { "cell_type": "code", "id": "f90c5a72", "metadata": { "ExecuteTime": { "end_time": "2024-12-11T16:03:58.986144Z", "start_time": "2024-12-11T16:03:58.962718Z" } }, "source": [ "def df2assocs(df):\n", " # TODO: why not use GAF adapter?\n", " for _, row in df.iterrows():\n", " yield Association(subject=row[GENE], object=row[TERM])\n", " \n", "def compare_gaf_dfs(df1, df2, preds=[IS_A, PART_OF]):\n", " \"\"\"\n", " Perform an association diff between two GAF DataFrames\n", " \"\"\"\n", " assocs1 = list(df2assocs(df1))\n", " assocs2 = list(df2assocs(df2))\n", " differ = AssociationDiffer(go)\n", " objs = []\n", " for ch in differ.calculate_change_objects(assocs1, assocs2, preds):\n", " objs.append(ch)\n", " return pd.DataFrame(objs).dropna(axis=1, how='all')\n", "\n", "compare_gaf_dfs(df1, df2, preds=[IS_A, PART_OF])" ], "outputs": [ { "ename": "NameError", "evalue": "name 'df1' is not defined", "output_type": "error", "traceback": [ "\u001B[0;31m---------------------------------------------------------------------------\u001B[0m", "\u001B[0;31mNameError\u001B[0m Traceback (most recent call last)", "Cell \u001B[0;32mIn[10], line 18\u001B[0m\n\u001B[1;32m 15\u001B[0m objs\u001B[38;5;241m.\u001B[39mappend(ch)\n\u001B[1;32m 16\u001B[0m \u001B[38;5;28;01mreturn\u001B[39;00m pd\u001B[38;5;241m.\u001B[39mDataFrame(objs)\u001B[38;5;241m.\u001B[39mdropna(axis\u001B[38;5;241m=\u001B[39m\u001B[38;5;241m1\u001B[39m, how\u001B[38;5;241m=\u001B[39m\u001B[38;5;124m'\u001B[39m\u001B[38;5;124mall\u001B[39m\u001B[38;5;124m'\u001B[39m)\n\u001B[0;32m---> 18\u001B[0m compare_gaf_dfs(\u001B[43mdf1\u001B[49m, df2, preds\u001B[38;5;241m=\u001B[39m[IS_A, PART_OF])\n", "\u001B[0;31mNameError\u001B[0m: name 'df1' is not defined" ] } ], "execution_count": 10 }, { "cell_type": "markdown", "id": "4a01f626", "metadata": {}, "source": [ "## Human GAF analysis" ] }, { "cell_type": "code", "execution_count": 89, "id": "a3fba8d6", "metadata": {}, "outputs": [], "source": [ "!mkdir -p input" ] }, { "cell_type": "code", "execution_count": 22, "id": "4a60c3f1", "metadata": {}, "outputs": [], "source": [ "!curl -L -s http://release.geneontology.org/2023-04-01/annotations/goa_human.gaf.gz | gzip -dc > input/goa_human.gaf" ] }, { "cell_type": "code", "id": "74f236ad", "metadata": { "ExecuteTime": { "end_time": "2024-12-11T17:14:56.356861Z", "start_time": "2024-12-11T17:14:56.165942Z" } }, "source": [ "!head input/goa_human.gaf" ], "outputs": [ { "name": "stdout", "output_type": "stream", "text": [ "!gaf-version: 2.2\r\n", "!\r\n", "!generated-by: GOC\r\n", "!\r\n", "!date-generated: 2023-04-02T12:17\r\n", "!\r\n", "!Header from source association file:\r\n", "!=================================\r\n", "!\r\n", "!generated-by: GOC\r\n" ] } ], "execution_count": 11 }, { "cell_type": "code", "id": "2294da07", "metadata": { "ExecuteTime": { "end_time": "2024-12-11T17:15:03.239513Z", "start_time": "2024-12-11T17:15:02.100293Z" } }, "source": [ "df = gaf2df(\"input/goa_human.gaf\")" ], "outputs": [ { "name": "stderr", "output_type": "stream", "text": [ "/var/folders/nc/m4tx21912kv1b8nk3zzx9plr0000gn/T/ipykernel_46260/614969007.py:2: DtypeWarning: Columns (15) have mixed types. Specify dtype option on import or set low_memory=False.\n", " df = pd.read_csv(path, sep=\"\\t\", comment=\"!\", names=[c.value for c in GafAssociationColumns])\n" ] } ], "execution_count": 12 }, { "cell_type": "code", "id": "c8449a9f", "metadata": { "ExecuteTime": { "end_time": "2024-12-11T17:15:58.501752Z", "start_time": "2024-12-11T17:15:58.488905Z" } }, "source": [ "df" ], "outputs": [ { "data": { "text/plain": [ " db local_id db_object_symbol qualifiers \\\n", "0 UniProtKB A0A024RBG1 NUDT4B enables \n", "1 UniProtKB A0A024RBG1 NUDT4B enables \n", "2 UniProtKB A0A024RBG1 NUDT4B located_in \n", "3 UniProtKB A0A075B6H7 IGKV3-7 involved_in \n", "4 UniProtKB A0A075B6H7 IGKV3-7 located_in \n", "... ... ... ... ... \n", "630736 UniProtKB P35580 MYH10 involved_in \n", "630737 UniProtKB Q10472 GALNT1 involved_in \n", "630738 UniProtKB Q6NXT2 H3-5 is_active_in \n", "630739 UniProtKB Q9NS87 KIF15 is_active_in \n", "630740 UniProtKB P01889 HLA-B is_active_in \n", "\n", " ontology_class_ref supporting_references evidence_type \\\n", "0 GO:0003723 GO_REF:0000043 IEA \n", "1 GO:0046872 GO_REF:0000043 IEA \n", "2 GO:0005829 GO_REF:0000052 IDA \n", "3 GO:0002250 GO_REF:0000043 IEA \n", "4 GO:0005886 GO_REF:0000044 IEA \n", "... ... ... ... \n", "630736 GO:0031032 PMID:21873635 IBA \n", "630737 GO:0006493 PMID:21873635 IBA \n", "630738 GO:0005634 PMID:21873635 IBA \n", "630739 GO:0005874 PMID:21873635 IBA \n", "630740 GO:0005615 PMID:21873635 IBA \n", "\n", " with_or_from aspect \\\n", "0 UniProtKB-KW:KW-0694 F \n", "1 UniProtKB-KW:KW-0479 F \n", "2 NaN C \n", "3 UniProtKB-KW:KW-1064 P \n", "4 UniProtKB-SubCell:SL-0039 C \n", "... ... ... \n", "630736 PANTHER:PTN002897265|UniProtKB:P35580|MGI:MGI:... P \n", "630737 PANTHER:PTN004287905|WB:WBGene00001630|UniProt... P \n", "630738 PANTHER:PTN008517671|dictyBase:DDB_G0271092|Un... C \n", "630739 PANTHER:PTN000648413|UniProtKB:C8V3Q8|UniProtK... C \n", "630740 PANTHER:PTN002703355|UniProtKB:Q30201|UniProtK... C \n", "\n", " db_object_name db_object_synonyms \\\n", "0 Diphosphoinositol polyphosphate phosphohydrola... NUDT4B \n", "1 Diphosphoinositol polyphosphate phosphohydrola... NUDT4B \n", "2 Diphosphoinositol polyphosphate phosphohydrola... NUDT4B \n", "3 Probable non-functional immunoglobulin kappa v... IGKV3-7 \n", "4 Probable non-functional immunoglobulin kappa v... IGKV3-7 \n", "... ... ... \n", "630736 Myosin-10 MYH10 \n", "630737 Polypeptide N-acetylgalactosaminyltransferase 1 GALNT1 \n", "630738 Histone H3.3C H3-5|H3F3C \n", "630739 Kinesin-like protein KIF15 KIF15|KLP2|KNSL7 \n", "630740 HLA class I histocompatibility antigen, B alph... 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0UniProtKBA0A024RBG1NUDT4BenablesGO:0003723GO_REF:0000043IEAUniProtKB-KW:KW-0694FDiphosphoinositol polyphosphate phosphohydrola...NUDT4Bproteintaxon:960620230306UniProtNaNNaN
1UniProtKBA0A024RBG1NUDT4BenablesGO:0046872GO_REF:0000043IEAUniProtKB-KW:KW-0479FDiphosphoinositol polyphosphate phosphohydrola...NUDT4Bproteintaxon:960620230306UniProtNaNNaN
2UniProtKBA0A024RBG1NUDT4Blocated_inGO:0005829GO_REF:0000052IDANaNCDiphosphoinositol polyphosphate phosphohydrola...NUDT4Bproteintaxon:960620161204HPANaNNaN
3UniProtKBA0A075B6H7IGKV3-7involved_inGO:0002250GO_REF:0000043IEAUniProtKB-KW:KW-1064PProbable non-functional immunoglobulin kappa v...IGKV3-7proteintaxon:960620230306UniProtNaNNaN
4UniProtKBA0A075B6H7IGKV3-7located_inGO:0005886GO_REF:0000044IEAUniProtKB-SubCell:SL-0039CProbable non-functional immunoglobulin kappa v...IGKV3-7proteintaxon:960620230306UniProtNaNNaN
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630736UniProtKBP35580MYH10involved_inGO:0031032PMID:21873635IBAPANTHER:PTN002897265|UniProtKB:P35580|MGI:MGI:...PMyosin-10MYH10proteintaxon:960620220223GO_CentralNaNNaN
630737UniProtKBQ10472GALNT1involved_inGO:0006493PMID:21873635IBAPANTHER:PTN004287905|WB:WBGene00001630|UniProt...PPolypeptide N-acetylgalactosaminyltransferase 1GALNT1proteintaxon:960620230110GO_CentralNaNNaN
630738UniProtKBQ6NXT2H3-5is_active_inGO:0005634PMID:21873635IBAPANTHER:PTN008517671|dictyBase:DDB_G0271092|Un...CHistone H3.3CH3-5|H3F3Cproteintaxon:960620230110GO_CentralNaNNaN
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630740UniProtKBP01889HLA-Bis_active_inGO:0005615PMID:21873635IBAPANTHER:PTN002703355|UniProtKB:Q30201|UniProtK...CHLA class I histocompatibility antigen, B alph...HLA-B|HLABproteintaxon:960620181121GO_CentralNaNNaN
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630741 rows × 17 columns

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" ] }, "execution_count": 13, "metadata": {}, "output_type": "execute_result" } ], "execution_count": 13 }, { "cell_type": "code", "id": "6500d6c3", "metadata": { "ExecuteTime": { "end_time": "2024-12-11T17:16:04.222196Z", "start_time": "2024-12-11T17:16:04.136973Z" } }, "source": [ "iea = df.query(\"evidence_type == 'IEA'\")\n", "iea.groupby(['supporting_references']).count()" ], "outputs": [ { "data": { "text/plain": [ " db local_id db_object_symbol qualifiers \\\n", "supporting_references \n", "GO_REF:0000002 6331 6331 6331 6331 \n", "GO_REF:0000003 1052 1052 1052 1052 \n", "GO_REF:0000041 738 738 738 738 \n", "GO_REF:0000043 13433 13433 13433 13433 \n", "GO_REF:0000044 8086 8086 8086 8086 \n", "GO_REF:0000104 199 199 199 199 \n", "GO_REF:0000107 39108 39108 39108 39108 \n", "GO_REF:0000108 3680 3680 3680 3680 \n", "GO_REF:0000116 1147 1147 1147 1147 \n", "GO_REF:0000117 214 214 214 214 \n", "\n", " ontology_class_ref evidence_type with_or_from \\\n", "supporting_references \n", "GO_REF:0000002 6331 6331 6331 \n", "GO_REF:0000003 1052 1052 1052 \n", "GO_REF:0000041 738 738 738 \n", "GO_REF:0000043 13433 13433 13433 \n", "GO_REF:0000044 8086 8086 8086 \n", "GO_REF:0000104 199 199 199 \n", "GO_REF:0000107 39108 39108 39108 \n", "GO_REF:0000108 3680 3680 3680 \n", "GO_REF:0000116 1147 1147 1147 \n", "GO_REF:0000117 214 214 214 \n", "\n", " aspect db_object_name db_object_synonyms \\\n", "supporting_references \n", "GO_REF:0000002 6331 6331 6321 \n", "GO_REF:0000003 1052 1052 1052 \n", "GO_REF:0000041 738 738 738 \n", "GO_REF:0000043 13433 13433 13418 \n", "GO_REF:0000044 8086 8086 8073 \n", "GO_REF:0000104 199 199 199 \n", "GO_REF:0000107 39108 39108 39108 \n", "GO_REF:0000108 3680 3680 3678 \n", "GO_REF:0000116 1147 1147 1147 \n", "GO_REF:0000117 214 214 213 \n", "\n", " db_object_type db_object_taxon annotation_date \\\n", "supporting_references \n", "GO_REF:0000002 6331 6331 6331 \n", "GO_REF:0000003 1052 1052 1052 \n", "GO_REF:0000041 738 738 738 \n", "GO_REF:0000043 13433 13433 13433 \n", "GO_REF:0000044 8086 8086 8086 \n", "GO_REF:0000104 199 199 199 \n", "GO_REF:0000107 39108 39108 39108 \n", "GO_REF:0000108 3680 3680 3680 \n", "GO_REF:0000116 1147 1147 1147 \n", "GO_REF:0000117 214 214 214 \n", "\n", " assigned_by annotation_extensions gene_product_form \n", "supporting_references \n", "GO_REF:0000002 6331 0 0 \n", "GO_REF:0000003 1052 0 0 \n", "GO_REF:0000041 738 0 0 \n", "GO_REF:0000043 13433 0 0 \n", "GO_REF:0000044 8086 0 0 \n", "GO_REF:0000104 199 0 0 \n", "GO_REF:0000107 39108 0 0 \n", "GO_REF:0000108 3680 0 0 \n", "GO_REF:0000116 1147 0 0 \n", "GO_REF:0000117 214 0 0 " ], "text/html": [ "
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GO_REF:000011721421421421421421421421421421321421421421400
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" ] }, "execution_count": 14, "metadata": {}, "output_type": "execute_result" } ], "execution_count": 14 }, { "cell_type": "markdown", "id": "2b66fe56", "metadata": {}, "source": [ "## Fetch all GOREFs" ] }, { "cell_type": "code", "id": "777cd22f", "metadata": { "ExecuteTime": { "end_time": "2024-12-11T17:16:26.797246Z", "start_time": "2024-12-11T17:16:26.787197Z" } }, "source": [ "gorefs = set(iea['supporting_references'])\n", "gorefs" ], "outputs": [ { "data": { "text/plain": [ "{'GO_REF:0000002',\n", " 'GO_REF:0000003',\n", " 'GO_REF:0000041',\n", " 'GO_REF:0000043',\n", " 'GO_REF:0000044',\n", " 'GO_REF:0000104',\n", " 'GO_REF:0000107',\n", " 'GO_REF:0000108',\n", " 'GO_REF:0000116',\n", " 'GO_REF:0000117'}" ] }, "execution_count": 15, "metadata": {}, "output_type": "execute_result" } ], "execution_count": 15 }, { "cell_type": "code", "id": "8682b70b", "metadata": { "ExecuteTime": { "end_time": "2024-12-11T17:16:35.613550Z", "start_time": "2024-12-11T17:16:35.608673Z" } }, "source": [ "def add_labels(df):\n", " \"\"\"\n", " Annotate Diff DataFrame with labels for the objects that are \"lost\"\n", " \"\"\"\n", " df[\"old_object_label\"] = df.apply(lambda row: go.label(row[\"old_object\"]), axis=1)" ], "outputs": [], "execution_count": 16 }, { "cell_type": "code", "id": "297b8916", "metadata": { "ExecuteTime": { "end_time": "2024-12-11T17:16:58.649577Z", "start_time": "2024-12-11T17:16:58.646441Z" } }, "source": [ "def analyze_iea(df, ref):\n", " \"\"\"\n", " Simulate deleting the IEAs with the stated reference.\n", " \"\"\"\n", " df_minus = df.query(f'supporting_references != \"{ref}\"')\n", " return compare_gaf_dfs(df, df_minus)" ], "outputs": [], "execution_count": 17 }, { "cell_type": "markdown", "id": "75f69dbe", "metadata": {}, "source": [ "## RHEA" ] }, { "cell_type": "code", "execution_count": 43, "id": "63c9766a", "metadata": {}, "outputs": [], "source": [ "rhea = analyze_iea(df, \"GO_REF:0000116\")" ] }, { "cell_type": "code", "execution_count": 66, "id": "b2931315", "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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publicationssubjectold_objectold_object_obsoleteis_deletionclosure_predicatesclosure_deltaold_object_label
0[]P22612GO:0106310FalseTrue[rdfs:subClassOf, BFO:0000050]-1protein serine kinase activity
1[]Q9Y3S1GO:0106310FalseTrue[rdfs:subClassOf, BFO:0000050]-1protein serine kinase activity
2[]Q9NUU7GO:0016887FalseTrue[rdfs:subClassOf, BFO:0000050]-6ATP hydrolysis activity
3[]Q16584GO:0106310FalseTrue[rdfs:subClassOf, BFO:0000050]-1protein serine kinase activity
4[]P17516GO:0047045FalseTrue[rdfs:subClassOf, BFO:0000050]-1testosterone 17-beta-dehydrogenase (NADP+) act...
...........................
720[]Q5VST9GO:0106310FalseTrue[rdfs:subClassOf, BFO:0000050]-1protein serine kinase activity
721[]O43293GO:0106310FalseTrue[rdfs:subClassOf, BFO:0000050]-1protein serine kinase activity
722[]Q9H2U1GO:0016887FalseTrue[rdfs:subClassOf, BFO:0000050]-6ATP hydrolysis activity
723[]Q6DHV7GO:0062154FalseTrue[rdfs:subClassOf, BFO:0000050]-1N6-methyl-AMP deaminase activity
724[]Q5TCX8GO:0106310FalseTrue[rdfs:subClassOf, BFO:0000050]-1protein serine kinase activity
\n", "

725 rows × 8 columns

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" ], "text/plain": [ " publications subject old_object old_object_obsolete is_deletion \\\n", "0 [] P22612 GO:0106310 False True \n", "1 [] Q9Y3S1 GO:0106310 False True \n", "2 [] Q9NUU7 GO:0016887 False True \n", "3 [] Q16584 GO:0106310 False True \n", "4 [] P17516 GO:0047045 False True \n", ".. ... ... ... ... ... \n", "720 [] Q5VST9 GO:0106310 False True \n", "721 [] O43293 GO:0106310 False True \n", "722 [] Q9H2U1 GO:0016887 False True \n", "723 [] Q6DHV7 GO:0062154 False True \n", "724 [] Q5TCX8 GO:0106310 False True \n", "\n", " closure_predicates closure_delta \\\n", "0 [rdfs:subClassOf, BFO:0000050] -1 \n", "1 [rdfs:subClassOf, BFO:0000050] -1 \n", "2 [rdfs:subClassOf, BFO:0000050] -6 \n", "3 [rdfs:subClassOf, BFO:0000050] -1 \n", "4 [rdfs:subClassOf, BFO:0000050] -1 \n", ".. ... ... \n", "720 [rdfs:subClassOf, BFO:0000050] -1 \n", "721 [rdfs:subClassOf, BFO:0000050] -1 \n", "722 [rdfs:subClassOf, BFO:0000050] -6 \n", "723 [rdfs:subClassOf, BFO:0000050] -1 \n", "724 [rdfs:subClassOf, BFO:0000050] -1 \n", "\n", " old_object_label \n", "0 protein serine kinase activity \n", "1 protein serine kinase activity \n", "2 ATP hydrolysis activity \n", "3 protein serine kinase activity \n", "4 testosterone 17-beta-dehydrogenase (NADP+) act... \n", ".. ... \n", "720 protein serine kinase activity \n", "721 protein serine kinase activity \n", "722 ATP hydrolysis activity \n", "723 N6-methyl-AMP deaminase activity \n", "724 protein serine kinase activity \n", "\n", "[725 rows x 8 columns]" ] }, "execution_count": 66, "metadata": {}, "output_type": "execute_result" } ], "source": [ "add_labels(rhea)\n", "rhea" ] }, { "cell_type": "code", "execution_count": 70, "id": "2db5ca88", "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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old_object_obsoleteis_deletionclosure_delta
old_objectold_object_label
GO:00020834-hydroxybenzoate decaprenyltransferase activity0.01.0-2.0
GO:0003924GTPase activity0.01.0-5.0
GO:0003954NADH dehydrogenase activity0.01.0-1.0
GO:0004052arachidonate 12(S)-lipoxygenase activity0.01.0-1.0
GO:00041153',5'-cyclic-AMP phosphodiesterase activity0.01.0-2.0
...............
GO:0140947histone H3K9me2 methyltransferase activity0.01.0-1.0
GO:0140948histone H3K9 monomethyltransferase activity0.01.0-1.0
GO:1901480oleate transmembrane transporter activity0.01.0-1.0
GO:1990002methylglyoxal reductase (NADPH-dependent, acetol producing)0.01.0-1.0
GO:1990362butanol dehydrogenase activity0.01.0-1.0
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153 rows × 3 columns

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" ], "text/plain": [ " old_object_obsolete \\\n", "old_object old_object_label \n", "GO:0002083 4-hydroxybenzoate decaprenyltransferase activity 0.0 \n", "GO:0003924 GTPase activity 0.0 \n", "GO:0003954 NADH dehydrogenase activity 0.0 \n", "GO:0004052 arachidonate 12(S)-lipoxygenase activity 0.0 \n", "GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 0.0 \n", "... ... \n", "GO:0140947 histone H3K9me2 methyltransferase activity 0.0 \n", "GO:0140948 histone H3K9 monomethyltransferase activity 0.0 \n", "GO:1901480 oleate transmembrane transporter activity 0.0 \n", "GO:1990002 methylglyoxal reductase (NADPH-dependent, aceto... 0.0 \n", "GO:1990362 butanol dehydrogenase activity 0.0 \n", "\n", " is_deletion \\\n", "old_object old_object_label \n", "GO:0002083 4-hydroxybenzoate decaprenyltransferase activity 1.0 \n", "GO:0003924 GTPase activity 1.0 \n", "GO:0003954 NADH dehydrogenase activity 1.0 \n", "GO:0004052 arachidonate 12(S)-lipoxygenase activity 1.0 \n", "GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1.0 \n", "... ... \n", "GO:0140947 histone H3K9me2 methyltransferase activity 1.0 \n", "GO:0140948 histone H3K9 monomethyltransferase activity 1.0 \n", "GO:1901480 oleate transmembrane transporter activity 1.0 \n", "GO:1990002 methylglyoxal reductase (NADPH-dependent, aceto... 1.0 \n", "GO:1990362 butanol dehydrogenase activity 1.0 \n", "\n", " closure_delta \n", "old_object old_object_label \n", "GO:0002083 4-hydroxybenzoate decaprenyltransferase activity -2.0 \n", "GO:0003924 GTPase activity -5.0 \n", "GO:0003954 NADH dehydrogenase activity -1.0 \n", "GO:0004052 arachidonate 12(S)-lipoxygenase activity -1.0 \n", "GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity -2.0 \n", "... ... \n", "GO:0140947 histone H3K9me2 methyltransferase activity -1.0 \n", "GO:0140948 histone H3K9 monomethyltransferase activity -1.0 \n", "GO:1901480 oleate transmembrane transporter activity -1.0 \n", "GO:1990002 methylglyoxal reductase (NADPH-dependent, aceto... -1.0 \n", "GO:1990362 butanol dehydrogenase activity -1.0 \n", "\n", "[153 rows x 3 columns]" ] }, "execution_count": 70, "metadata": {}, "output_type": "execute_result" } ], "source": [ "lbl = ['old_object', 'old_object_label']\n", "rhea.groupby(lbl).mean(numeric_only=True)" ] }, { "cell_type": "code", "execution_count": 73, "id": "693d966a", "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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old_object_obsoleteis_deletionclosure_delta
old_objectold_object_label
GO:0016279protein-lysine N-methyltransferase activityFalseTrue-10
GO:01409335'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activityFalseTrue-9
GO:0016887ATP hydrolysis activityFalseTrue-7
GO:0003924GTPase activityFalseTrue-7
GO:0052665tRNA (uracil-2'-O-)-methyltransferase activityFalseTrue-4
GO:003613412-hydroxyheptadecatrienoic acid synthase activityFalseTrue-4
GO:0004713protein tyrosine kinase activityFalseTrue-4
GO:0090555phosphatidylethanolamine flippase activityFalseTrue-4
GO:0097023fructose 6-phosphate aldolase activityFalseTrue-4
GO:0004165delta(3)-delta(2)-enoyl-CoA isomerase activityFalseTrue-4
GO:0106294NADPH oxidase H202-forming activityFalseTrue-4
GO:0090556phosphatidylserine floppase activityFalseTrue-3
GO:0047748cholestanetetraol 26-dehydrogenase activityFalseTrue-3
GO:0016290palmitoyl-CoA hydrolase activityFalseTrue-3
GO:0004722protein serine/threonine phosphatase activityFalseTrue-3
GO:00041153',5'-cyclic-AMP phosphodiesterase activityFalseTrue-3
GO:0140567membrane protein dislocase activityFalseTrue-3
GO:0047045testosterone 17-beta-dehydrogenase (NADP+) activityFalseTrue-3
GO:0008458carnitine O-octanoyltransferase activityFalseTrue-3
GO:0102391decanoate-CoA ligase activityFalseTrue-2
GO:0047956glycerol dehydrogenase [NADP+] activityFalseTrue-2
GO:0062189anandamide 14,15 epoxidase activityFalseTrue-2
GO:0043262ADP phosphatase activityFalseTrue-2
GO:0106347U2 snRNA 2'-O-methyladenosine m6 methyltransferase activityFalseTrue-2
GO:0042054histone methyltransferase activityFalseTrue-2
GO:0034485phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activityFalseTrue-2
GO:0047451(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activityFalseTrue-2
GO:0043759methylbutanoate-CoA ligase activityFalseTrue-2
GO:0106156peptidyl-lysine 4-dioxygenase activityFalseTrue-2
GO:004459417-beta-hydroxysteroid dehydrogenase (NAD+) activityFalseTrue-2
GO:0047376all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activityFalseTrue-2
GO:01063644-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activityFalseTrue-2
GO:0034480phosphatidylcholine phospholipase C activityFalseTrue-2
GO:00020834-hydroxybenzoate decaprenyltransferase activityFalseTrue-2
GO:0047035testosterone dehydrogenase (NAD+) activityFalseTrue-2
GO:0062188anandamide 11,12 epoxidase activityFalseTrue-2
GO:0062187anandamide 8,9 epoxidase activityFalseTrue-2
GO:0090554phosphatidylcholine floppase activityFalseTrue-2
GO:0004317(3R)-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activityFalseTrue-2
GO:0051922cholesterol sulfotransferase activityFalseTrue-2
GO:0004439phosphatidylinositol-4,5-bisphosphate 5-phosphatase activityFalseTrue-2
GO:0016312inositol bisphosphate phosphatase activityFalseTrue-2
GO:0052848inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activityFalseTrue-2
GO:0015417ABC-type polyamine transporter activityFalseTrue-2
GO:0008106alcohol dehydrogenase (NADP+) activityFalseTrue-2
GO:0052845inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activityFalseTrue-2
GO:0008970phospholipase A1 activityFalseTrue-2
GO:0019705protein-cysteine S-myristoyltransferase activityFalseTrue-2
GO:0008693(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activityFalseTrue-2
GO:0106009(4S)-4-hydroxy-2-oxoglutarate aldolase activityFalseTrue-1
GO:01023363-oxo-arachidoyl-CoA synthase activityFalseTrue-1
GO:0103026fructose-1-phosphatase activityFalseTrue-1
GO:0098606selenocystathionine gamma-lyase activityFalseTrue-1
GO:0102991myristoyl-CoA hydrolase activityFalseTrue-1
GO:0102662malonate-semialdehyde dehydrogenase (acetylating, NAD+) activityFalseTrue-1
GO:010235411-cis-retinol dehydrogenase activityFalseTrue-1
GO:0102149farnesylcysteine lyase activityFalseTrue-1
GO:01021753-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activityFalseTrue-1
GO:01023383-oxo-lignoceronyl-CoA synthase activityFalseTrue-1
GO:01023373-oxo-cerotoyl-CoA synthase activityFalseTrue-1
GO:01060082-oxoglutaramate amidase activityFalseTrue-1
GO:0097383dIDP phosphatase activityFalseTrue-1
GO:0106375deoxynucleoside triphosphate hydrolase activityFalseTrue-1
GO:0106237arachidonate 12(R)-lipoxygenase activityFalseTrue-1
GO:1901480oleate transmembrane transporter activityFalseTrue-1
GO:0140948histone H3K9 monomethyltransferase activityFalseTrue-1
GO:0140947histone H3K9me2 methyltransferase activityFalseTrue-1
GO:0140945histone H3K4 monomethyltransferase activityFalseTrue-1
GO:0140944histone H4K20 monomethyltransferase activityFalseTrue-1
GO:0140943histone H4K20 trimethyltransferase activityFalseTrue-1
GO:0140941histone H4K20me methyltransferase activityFalseTrue-1
GO:0140818mRNA 5'-phosphatase activityFalseTrue-1
GO:0140804NAD+- protein-lysine ADP-ribosyltransferase activityFalseTrue-1
GO:0140803NAD+- protein-cysteine ADP-ribosyltransferase activityFalseTrue-1
GO:0140683histone H3K9me/H3K9me2 demethylase activityFalseTrue-1
GO:0140562EGF-domain serine xylosyltransferase activityFalseTrue-1
GO:0140561EGF-domain serine glucosyltransferase activityFalseTrue-1
GO:0106226peptide 2-hydroxyisobutyryltransferase activityFalseTrue-1
GO:0140439protein-cysteine S-stearoyltransferase activityFalseTrue-1
GO:01202432-iminopropanoate deaminase activityFalseTrue-1
GO:0120092crotonyl-CoA hydratase activityFalseTrue-1
GO:0110153RNA NAD-cap (NMN-forming) hydrolase activityFalseTrue-1
GO:0106433O6-methyl-dGTP hydrolase activityFalseTrue-1
GO:0106431N6-methyl-(d)ATP hydrolase activityFalseTrue-1
GO:0106399acyl-coenzyme A diphosphatase activityFalseTrue-1
GO:0106386(3R)-hydroxyacyl-CoA dehydrogenase (NAD) activityFalseTrue-1
GO:01063762-hydroxyphytanoyl-CoA lyase activityFalseTrue-1
GO:0106329L-phenylalaine oxidase activityFalseTrue-1
GO:0106313methylenetetrahydrofolate reductase NADPH activityFalseTrue-1
GO:0106310protein serine kinase activityFalseTrue-1
GO:0106301arachidonic acid 5,6-epoxygenase activityFalseTrue-1
GO:0106293NADH oxidase H202-forming activityFalseTrue-1
GO:0120298peptide noradrenalinyltransferase activityFalseTrue-1
GO:0080079cellobiose glucosidase activityFalseTrue-1
GO:0047982homocysteine desulfhydrase activityFalseTrue-1
GO:0070251pristanate-CoA ligase activityFalseTrue-1
GO:0036220ITP diphosphatase activityFalseTrue-1
GO:0036219GTP diphosphatase activityFalseTrue-1
GO:0036218dTTP diphosphatase activityFalseTrue-1
GO:0036130prostaglandin H2 endoperoxidase reductase activityFalseTrue-1
GO:0035870dITP diphosphatase activityFalseTrue-1
GO:0035242protein-arginine omega-N asymmetric methyltransferase activityFalseTrue-1
GO:0035241protein-arginine omega-N monomethyltransferase activityFalseTrue-1
GO:00337795beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activityFalseTrue-1
GO:00337033beta-hydroxy-5beta-steroid dehydrogenase activityFalseTrue-1
GO:0031956medium-chain fatty acid-CoA ligase activityFalseTrue-1
GO:0018820cyanamide hydratase activityFalseTrue-1
GO:00166174-oxoproline reductase activityFalseTrue-1
GO:0010308acireductone dioxygenase (Ni2+-requiring) activityFalseTrue-1
GO:0008983protein-glutamate O-methyltransferase activityFalseTrue-1
GO:0008753NADPH dehydrogenase (quinone) activityFalseTrue-1
GO:0008405arachidonic acid 11,12-epoxygenase activityFalseTrue-1
GO:0008404arachidonic acid 14,15-epoxygenase activityFalseTrue-1
GO:0004806triglyceride lipase activityFalseTrue-1
GO:0004745NAD-retinol dehydrogenase activityFalseTrue-1
GO:0004427inorganic diphosphate phosphatase activityFalseTrue-1
GO:0004354glutamate dehydrogenase (NADP+) activityFalseTrue-1
GO:0004336galactosylceramidase activityFalseTrue-1
GO:0004180carboxypeptidase activityFalseTrue-1
GO:0004052arachidonate 12(S)-lipoxygenase activityFalseTrue-1
GO:0003954NADH dehydrogenase activityFalseTrue-1
GO:0036221UTP diphosphatase activityFalseTrue-1
GO:007258217-beta-hydroxysteroid dehydrogenase (NADP+) activityFalseTrue-1
GO:0036222XTP diphosphatase activityFalseTrue-1
GO:0036430CMP kinase activityFalseTrue-1
GO:0062184testosterone 16-beta-hydroxylase activityFalseTrue-1
GO:0062183all-trans retinoic acid 18-hydroxylase activityFalseTrue-1
GO:0062182all-trans retinoic acid 4-hydrolase activityFalseTrue-1
GO:0062154N6-methyl-AMP deaminase activityFalseTrue-1
GO:0052596phenethylamine:oxygen oxidoreductase (deaminating) activityFalseTrue-1
GO:0052595aliphatic amine oxidase activityFalseTrue-1
GO:0050213progesterone 5-alpha-reductase activityFalseTrue-1
GO:0050048L-leucine:2-oxoglutarate aminotransferase activityFalseTrue-1
GO:0047995hydroxyphenylpyruvate reductase activityFalseTrue-1
GO:1990002methylglyoxal reductase (NADPH-dependent, acetol producing)FalseTrue-1
GO:0047975guanosine phosphorylase activityFalseTrue-1
GO:0047935glucose 1-dehydrogenase (NADP+) activityFalseTrue-1
GO:0036403arachidonate 8(S)-lipoxygenase activityFalseTrue-1
GO:0047934glucose 1-dehydrogenase (NAD+) activityFalseTrue-1
GO:0047844deoxycytidine deaminase activityFalseTrue-1
GO:0047693ATP diphosphatase activityFalseTrue-1
GO:0047638albendazole monooxygenase activityFalseTrue-1
GO:00475553',5'-cyclic-GMP phosphodiesterase activityFalseTrue-1
GO:0047378acetylalkylglycerol acetylhydrolase activityFalseTrue-1
GO:00470227-beta-hydroxysteroid dehydrogenase (NADP+) activityFalseTrue-1
GO:0046899nucleoside triphosphate adenylate kinase activityFalseTrue-1
GO:00439563-hydroxypropionyl-CoA dehydratase activityFalseTrue-1
GO:0043878glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activityFalseTrue-1
GO:0043273CTPase activityFalseTrue-1
GO:0036431dCMP kinase activityFalseTrue-1
GO:0047931glucosamine kinase activityFalseTrue-1
GO:1990362butanol dehydrogenase activityFalseTrue-1
GO:0016937short-chain-acyl-CoA dehydrogenase activityFalseTrue0
\n", "
" ], "text/plain": [ " old_object_obsolete \\\n", "old_object old_object_label \n", "GO:0016279 protein-lysine N-methyltransferase activity False \n", "GO:0140933 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] ... False \n", "GO:0016887 ATP hydrolysis activity False \n", "GO:0003924 GTPase activity False \n", "GO:0052665 tRNA (uracil-2'-O-)-methyltransferase activity False \n", "GO:0036134 12-hydroxyheptadecatrienoic acid synthase activity False \n", "GO:0004713 protein tyrosine kinase activity False \n", "GO:0090555 phosphatidylethanolamine flippase activity False \n", "GO:0097023 fructose 6-phosphate aldolase activity False \n", "GO:0004165 delta(3)-delta(2)-enoyl-CoA isomerase activity False \n", "GO:0106294 NADPH oxidase H202-forming activity False \n", "GO:0090556 phosphatidylserine floppase activity False \n", "GO:0047748 cholestanetetraol 26-dehydrogenase activity False \n", "GO:0016290 palmitoyl-CoA hydrolase activity False \n", "GO:0004722 protein serine/threonine phosphatase activity False \n", "GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity False \n", "GO:0140567 membrane protein dislocase activity False \n", "GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) acti... False \n", "GO:0008458 carnitine O-octanoyltransferase activity False \n", "GO:0102391 decanoate-CoA ligase activity False \n", "GO:0047956 glycerol dehydrogenase [NADP+] activity False \n", "GO:0062189 anandamide 14,15 epoxidase activity False \n", "GO:0043262 ADP phosphatase activity False \n", "GO:0106347 U2 snRNA 2'-O-methyladenosine m6 methyltransfer... False \n", "GO:0042054 histone methyltransferase activity False \n", "GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phos... False \n", "GO:0047451 (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] d... False \n", "GO:0043759 methylbutanoate-CoA ligase activity False \n", "GO:0106156 peptidyl-lysine 4-dioxygenase activity False \n", "GO:0044594 17-beta-hydroxysteroid dehydrogenase (NAD+) act... False \n", "GO:0047376 all-trans-retinyl-palmitate hydrolase, all-tran... False \n", "GO:0106364 4-hydroxy-3-all-trans-hexaprenylbenzoate oxygen... False \n", "GO:0034480 phosphatidylcholine phospholipase C activity False \n", "GO:0002083 4-hydroxybenzoate decaprenyltransferase activity False \n", "GO:0047035 testosterone dehydrogenase (NAD+) activity False \n", "GO:0062188 anandamide 11,12 epoxidase activity False \n", "GO:0062187 anandamide 8,9 epoxidase activity False \n", "GO:0090554 phosphatidylcholine floppase activity False \n", "GO:0004317 (3R)-hydroxypalmitoyl-[acyl-carrier-protein] de... False \n", "GO:0051922 cholesterol sulfotransferase activity False \n", "GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phospha... False \n", "GO:0016312 inositol bisphosphate phosphatase activity False \n", "GO:0052848 inositol-3,5-bisdiphosphate-2,3,4,6-tetrakispho... False \n", "GO:0015417 ABC-type polyamine transporter activity False \n", "GO:0008106 alcohol dehydrogenase (NADP+) activity False \n", "GO:0052845 inositol-5-diphosphate-1,2,3,4,6-pentakisphosph... False \n", "GO:0008970 phospholipase A1 activity False \n", "GO:0019705 protein-cysteine S-myristoyltransferase activity False \n", "GO:0008693 (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] d... False \n", "GO:0106009 (4S)-4-hydroxy-2-oxoglutarate aldolase activity False \n", "GO:0102336 3-oxo-arachidoyl-CoA synthase activity False \n", "GO:0103026 fructose-1-phosphatase activity False \n", "GO:0098606 selenocystathionine gamma-lyase activity False \n", "GO:0102991 myristoyl-CoA hydrolase activity False \n", "GO:0102662 malonate-semialdehyde dehydrogenase (acetylatin... False \n", "GO:0102354 11-cis-retinol dehydrogenase activity False \n", "GO:0102149 farnesylcysteine lyase activity False \n", "GO:0102175 3-beta-hydroxysteroid dehydrogenase/C4-decarbox... False \n", "GO:0102338 3-oxo-lignoceronyl-CoA synthase activity False \n", "GO:0102337 3-oxo-cerotoyl-CoA synthase activity False \n", "GO:0106008 2-oxoglutaramate amidase activity False \n", "GO:0097383 dIDP phosphatase activity False \n", "GO:0106375 deoxynucleoside triphosphate hydrolase activity False \n", "GO:0106237 arachidonate 12(R)-lipoxygenase activity False \n", "GO:1901480 oleate transmembrane transporter activity False \n", "GO:0140948 histone H3K9 monomethyltransferase activity False \n", "GO:0140947 histone H3K9me2 methyltransferase activity False \n", "GO:0140945 histone H3K4 monomethyltransferase activity False \n", "GO:0140944 histone H4K20 monomethyltransferase activity False \n", "GO:0140943 histone H4K20 trimethyltransferase activity False \n", "GO:0140941 histone H4K20me methyltransferase activity False \n", "GO:0140818 mRNA 5'-phosphatase activity False \n", "GO:0140804 NAD+- protein-lysine ADP-ribosyltransferase act... False \n", "GO:0140803 NAD+- protein-cysteine ADP-ribosyltransferase a... False \n", "GO:0140683 histone H3K9me/H3K9me2 demethylase activity False \n", "GO:0140562 EGF-domain serine xylosyltransferase activity False \n", "GO:0140561 EGF-domain serine glucosyltransferase activity False \n", "GO:0106226 peptide 2-hydroxyisobutyryltransferase activity False \n", "GO:0140439 protein-cysteine S-stearoyltransferase activity False \n", "GO:0120243 2-iminopropanoate deaminase activity False \n", "GO:0120092 crotonyl-CoA hydratase activity False \n", "GO:0110153 RNA NAD-cap (NMN-forming) hydrolase activity False \n", "GO:0106433 O6-methyl-dGTP hydrolase activity False \n", "GO:0106431 N6-methyl-(d)ATP hydrolase activity False \n", "GO:0106399 acyl-coenzyme A diphosphatase activity False \n", "GO:0106386 (3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity False \n", "GO:0106376 2-hydroxyphytanoyl-CoA lyase activity False \n", "GO:0106329 L-phenylalaine oxidase activity False \n", "GO:0106313 methylenetetrahydrofolate reductase NADPH activity False \n", "GO:0106310 protein serine kinase activity False \n", "GO:0106301 arachidonic acid 5,6-epoxygenase activity False \n", "GO:0106293 NADH oxidase H202-forming activity False \n", "GO:0120298 peptide noradrenalinyltransferase activity False \n", "GO:0080079 cellobiose glucosidase activity False \n", "GO:0047982 homocysteine desulfhydrase activity False \n", "GO:0070251 pristanate-CoA ligase activity False \n", "GO:0036220 ITP diphosphatase activity False \n", "GO:0036219 GTP diphosphatase activity False \n", "GO:0036218 dTTP diphosphatase activity False \n", "GO:0036130 prostaglandin H2 endoperoxidase reductase activity False \n", "GO:0035870 dITP diphosphatase activity False \n", "GO:0035242 protein-arginine omega-N asymmetric methyltrans... False \n", "GO:0035241 protein-arginine omega-N monomethyltransferase ... False \n", "GO:0033779 5beta-cholestane-3alpha,7alpha-diol 12alpha-hyd... False \n", "GO:0033703 3beta-hydroxy-5beta-steroid dehydrogenase activity False \n", "GO:0031956 medium-chain fatty acid-CoA ligase activity False \n", "GO:0018820 cyanamide hydratase activity False \n", "GO:0016617 4-oxoproline reductase activity False \n", "GO:0010308 acireductone dioxygenase (Ni2+-requiring) activity False \n", "GO:0008983 protein-glutamate O-methyltransferase activity False \n", "GO:0008753 NADPH dehydrogenase (quinone) activity False \n", "GO:0008405 arachidonic acid 11,12-epoxygenase activity False \n", "GO:0008404 arachidonic acid 14,15-epoxygenase activity False \n", "GO:0004806 triglyceride lipase activity False \n", "GO:0004745 NAD-retinol dehydrogenase activity False \n", "GO:0004427 inorganic diphosphate phosphatase activity False \n", "GO:0004354 glutamate dehydrogenase (NADP+) activity False \n", "GO:0004336 galactosylceramidase activity False \n", "GO:0004180 carboxypeptidase activity False \n", "GO:0004052 arachidonate 12(S)-lipoxygenase activity False \n", "GO:0003954 NADH dehydrogenase activity False \n", "GO:0036221 UTP diphosphatase activity False \n", "GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) ac... False \n", "GO:0036222 XTP diphosphatase activity False \n", "GO:0036430 CMP kinase activity False \n", "GO:0062184 testosterone 16-beta-hydroxylase activity False \n", "GO:0062183 all-trans retinoic acid 18-hydroxylase activity False \n", "GO:0062182 all-trans retinoic acid 4-hydrolase activity False \n", "GO:0062154 N6-methyl-AMP deaminase activity False \n", "GO:0052596 phenethylamine:oxygen oxidoreductase (deaminati... False \n", "GO:0052595 aliphatic amine oxidase activity False \n", "GO:0050213 progesterone 5-alpha-reductase activity False \n", "GO:0050048 L-leucine:2-oxoglutarate aminotransferase activity False \n", "GO:0047995 hydroxyphenylpyruvate reductase activity False \n", "GO:1990002 methylglyoxal reductase (NADPH-dependent, aceto... False \n", "GO:0047975 guanosine phosphorylase activity False \n", "GO:0047935 glucose 1-dehydrogenase (NADP+) activity False \n", "GO:0036403 arachidonate 8(S)-lipoxygenase activity False \n", "GO:0047934 glucose 1-dehydrogenase (NAD+) activity False \n", "GO:0047844 deoxycytidine deaminase activity False \n", "GO:0047693 ATP diphosphatase activity False \n", "GO:0047638 albendazole monooxygenase activity False \n", "GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity False \n", "GO:0047378 acetylalkylglycerol acetylhydrolase activity False \n", "GO:0047022 7-beta-hydroxysteroid dehydrogenase (NADP+) act... False \n", "GO:0046899 nucleoside triphosphate adenylate kinase activity False \n", "GO:0043956 3-hydroxypropionyl-CoA dehydratase activity False \n", "GO:0043878 glyceraldehyde-3-phosphate dehydrogenase (NAD+)... False \n", "GO:0043273 CTPase activity False \n", "GO:0036431 dCMP kinase activity False \n", "GO:0047931 glucosamine kinase activity False \n", "GO:1990362 butanol dehydrogenase activity False \n", "GO:0016937 short-chain-acyl-CoA dehydrogenase activity False \n", "\n", " is_deletion \\\n", "old_object old_object_label \n", "GO:0016279 protein-lysine N-methyltransferase activity True \n", "GO:0140933 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] ... True \n", "GO:0016887 ATP hydrolysis activity True \n", "GO:0003924 GTPase activity True \n", "GO:0052665 tRNA (uracil-2'-O-)-methyltransferase activity True \n", "GO:0036134 12-hydroxyheptadecatrienoic acid synthase activity True \n", "GO:0004713 protein tyrosine kinase activity True \n", "GO:0090555 phosphatidylethanolamine flippase activity True \n", "GO:0097023 fructose 6-phosphate aldolase activity True \n", "GO:0004165 delta(3)-delta(2)-enoyl-CoA isomerase activity True \n", "GO:0106294 NADPH oxidase H202-forming activity True \n", "GO:0090556 phosphatidylserine floppase activity True \n", "GO:0047748 cholestanetetraol 26-dehydrogenase activity True \n", "GO:0016290 palmitoyl-CoA hydrolase activity True \n", "GO:0004722 protein serine/threonine phosphatase activity True \n", "GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity True \n", "GO:0140567 membrane protein dislocase activity True \n", "GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) acti... True \n", "GO:0008458 carnitine O-octanoyltransferase activity True \n", "GO:0102391 decanoate-CoA ligase activity True \n", "GO:0047956 glycerol dehydrogenase [NADP+] activity True \n", "GO:0062189 anandamide 14,15 epoxidase activity True \n", "GO:0043262 ADP phosphatase activity True \n", "GO:0106347 U2 snRNA 2'-O-methyladenosine m6 methyltransfer... True \n", "GO:0042054 histone methyltransferase activity True \n", "GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phos... True \n", "GO:0047451 (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] d... True \n", "GO:0043759 methylbutanoate-CoA ligase activity True \n", "GO:0106156 peptidyl-lysine 4-dioxygenase activity True \n", "GO:0044594 17-beta-hydroxysteroid dehydrogenase (NAD+) act... True \n", "GO:0047376 all-trans-retinyl-palmitate hydrolase, all-tran... True \n", "GO:0106364 4-hydroxy-3-all-trans-hexaprenylbenzoate oxygen... True \n", "GO:0034480 phosphatidylcholine phospholipase C activity True \n", "GO:0002083 4-hydroxybenzoate decaprenyltransferase activity True \n", "GO:0047035 testosterone dehydrogenase (NAD+) activity True \n", "GO:0062188 anandamide 11,12 epoxidase activity True \n", "GO:0062187 anandamide 8,9 epoxidase activity True \n", "GO:0090554 phosphatidylcholine floppase activity True \n", "GO:0004317 (3R)-hydroxypalmitoyl-[acyl-carrier-protein] de... True \n", "GO:0051922 cholesterol sulfotransferase activity True \n", "GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phospha... True \n", "GO:0016312 inositol bisphosphate phosphatase activity True \n", "GO:0052848 inositol-3,5-bisdiphosphate-2,3,4,6-tetrakispho... True \n", "GO:0015417 ABC-type polyamine transporter activity True \n", "GO:0008106 alcohol dehydrogenase (NADP+) activity True \n", "GO:0052845 inositol-5-diphosphate-1,2,3,4,6-pentakisphosph... True \n", "GO:0008970 phospholipase A1 activity True \n", "GO:0019705 protein-cysteine S-myristoyltransferase activity True \n", "GO:0008693 (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] d... True \n", "GO:0106009 (4S)-4-hydroxy-2-oxoglutarate aldolase activity True \n", "GO:0102336 3-oxo-arachidoyl-CoA synthase activity True \n", "GO:0103026 fructose-1-phosphatase activity True \n", "GO:0098606 selenocystathionine gamma-lyase activity True \n", "GO:0102991 myristoyl-CoA hydrolase activity True \n", "GO:0102662 malonate-semialdehyde dehydrogenase (acetylatin... True \n", "GO:0102354 11-cis-retinol dehydrogenase activity True \n", "GO:0102149 farnesylcysteine lyase activity True \n", "GO:0102175 3-beta-hydroxysteroid dehydrogenase/C4-decarbox... True \n", "GO:0102338 3-oxo-lignoceronyl-CoA synthase activity True \n", "GO:0102337 3-oxo-cerotoyl-CoA synthase activity True \n", "GO:0106008 2-oxoglutaramate amidase activity True \n", "GO:0097383 dIDP phosphatase activity True \n", "GO:0106375 deoxynucleoside triphosphate hydrolase activity True \n", "GO:0106237 arachidonate 12(R)-lipoxygenase activity True \n", "GO:1901480 oleate transmembrane transporter activity True \n", "GO:0140948 histone H3K9 monomethyltransferase activity True \n", "GO:0140947 histone H3K9me2 methyltransferase activity True \n", "GO:0140945 histone H3K4 monomethyltransferase activity True \n", "GO:0140944 histone H4K20 monomethyltransferase activity True \n", "GO:0140943 histone H4K20 trimethyltransferase activity True \n", "GO:0140941 histone H4K20me methyltransferase activity True \n", "GO:0140818 mRNA 5'-phosphatase activity True \n", "GO:0140804 NAD+- protein-lysine ADP-ribosyltransferase act... True \n", "GO:0140803 NAD+- protein-cysteine ADP-ribosyltransferase a... True \n", "GO:0140683 histone H3K9me/H3K9me2 demethylase activity True \n", "GO:0140562 EGF-domain serine xylosyltransferase activity True \n", "GO:0140561 EGF-domain serine glucosyltransferase activity True \n", "GO:0106226 peptide 2-hydroxyisobutyryltransferase activity True \n", "GO:0140439 protein-cysteine S-stearoyltransferase activity True \n", "GO:0120243 2-iminopropanoate deaminase activity True \n", "GO:0120092 crotonyl-CoA hydratase activity True \n", "GO:0110153 RNA NAD-cap (NMN-forming) hydrolase activity True \n", "GO:0106433 O6-methyl-dGTP hydrolase activity True \n", "GO:0106431 N6-methyl-(d)ATP hydrolase activity True \n", "GO:0106399 acyl-coenzyme A diphosphatase activity True \n", "GO:0106386 (3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity True \n", "GO:0106376 2-hydroxyphytanoyl-CoA lyase activity True \n", "GO:0106329 L-phenylalaine oxidase activity True \n", "GO:0106313 methylenetetrahydrofolate reductase NADPH activity True \n", "GO:0106310 protein serine kinase activity True \n", "GO:0106301 arachidonic acid 5,6-epoxygenase activity True \n", "GO:0106293 NADH oxidase H202-forming activity True \n", "GO:0120298 peptide noradrenalinyltransferase activity True \n", "GO:0080079 cellobiose glucosidase activity True \n", "GO:0047982 homocysteine desulfhydrase activity True \n", "GO:0070251 pristanate-CoA ligase activity True \n", "GO:0036220 ITP diphosphatase activity True \n", "GO:0036219 GTP diphosphatase activity True \n", "GO:0036218 dTTP diphosphatase activity True \n", "GO:0036130 prostaglandin H2 endoperoxidase reductase activity True \n", "GO:0035870 dITP diphosphatase activity True \n", "GO:0035242 protein-arginine omega-N asymmetric methyltrans... True \n", "GO:0035241 protein-arginine omega-N monomethyltransferase ... True \n", "GO:0033779 5beta-cholestane-3alpha,7alpha-diol 12alpha-hyd... True \n", "GO:0033703 3beta-hydroxy-5beta-steroid dehydrogenase activity True \n", "GO:0031956 medium-chain fatty acid-CoA ligase activity True \n", "GO:0018820 cyanamide hydratase activity True \n", "GO:0016617 4-oxoproline reductase activity True \n", "GO:0010308 acireductone dioxygenase (Ni2+-requiring) activity True \n", "GO:0008983 protein-glutamate O-methyltransferase activity True \n", "GO:0008753 NADPH dehydrogenase (quinone) activity True \n", "GO:0008405 arachidonic acid 11,12-epoxygenase activity True \n", "GO:0008404 arachidonic acid 14,15-epoxygenase activity True \n", "GO:0004806 triglyceride lipase activity True \n", "GO:0004745 NAD-retinol dehydrogenase activity True \n", "GO:0004427 inorganic diphosphate phosphatase activity True \n", "GO:0004354 glutamate dehydrogenase (NADP+) activity True \n", "GO:0004336 galactosylceramidase activity True \n", "GO:0004180 carboxypeptidase activity True \n", "GO:0004052 arachidonate 12(S)-lipoxygenase activity True \n", "GO:0003954 NADH dehydrogenase activity True \n", "GO:0036221 UTP diphosphatase activity True \n", "GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) ac... True \n", "GO:0036222 XTP diphosphatase activity True \n", "GO:0036430 CMP kinase activity True \n", "GO:0062184 testosterone 16-beta-hydroxylase activity True \n", "GO:0062183 all-trans retinoic acid 18-hydroxylase activity True \n", "GO:0062182 all-trans retinoic acid 4-hydrolase activity True \n", "GO:0062154 N6-methyl-AMP deaminase activity True \n", "GO:0052596 phenethylamine:oxygen oxidoreductase (deaminati... True \n", "GO:0052595 aliphatic amine oxidase activity True \n", "GO:0050213 progesterone 5-alpha-reductase activity True \n", "GO:0050048 L-leucine:2-oxoglutarate aminotransferase activity True \n", "GO:0047995 hydroxyphenylpyruvate reductase activity True \n", "GO:1990002 methylglyoxal reductase (NADPH-dependent, aceto... True \n", "GO:0047975 guanosine phosphorylase activity True \n", "GO:0047935 glucose 1-dehydrogenase (NADP+) activity True \n", "GO:0036403 arachidonate 8(S)-lipoxygenase activity True \n", "GO:0047934 glucose 1-dehydrogenase (NAD+) activity True \n", "GO:0047844 deoxycytidine deaminase activity True \n", "GO:0047693 ATP diphosphatase activity True \n", "GO:0047638 albendazole monooxygenase activity True \n", "GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity True \n", "GO:0047378 acetylalkylglycerol acetylhydrolase activity True \n", "GO:0047022 7-beta-hydroxysteroid dehydrogenase (NADP+) act... True \n", "GO:0046899 nucleoside triphosphate adenylate kinase activity True \n", "GO:0043956 3-hydroxypropionyl-CoA dehydratase activity True \n", "GO:0043878 glyceraldehyde-3-phosphate dehydrogenase (NAD+)... True \n", "GO:0043273 CTPase activity True \n", "GO:0036431 dCMP kinase activity True \n", "GO:0047931 glucosamine kinase activity True \n", "GO:1990362 butanol dehydrogenase activity True \n", "GO:0016937 short-chain-acyl-CoA dehydrogenase activity True \n", "\n", " closure_delta \n", "old_object old_object_label \n", "GO:0016279 protein-lysine N-methyltransferase activity -10 \n", "GO:0140933 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] ... -9 \n", "GO:0016887 ATP hydrolysis activity -7 \n", "GO:0003924 GTPase activity -7 \n", "GO:0052665 tRNA (uracil-2'-O-)-methyltransferase activity -4 \n", "GO:0036134 12-hydroxyheptadecatrienoic acid synthase activity -4 \n", "GO:0004713 protein tyrosine kinase activity -4 \n", "GO:0090555 phosphatidylethanolamine flippase activity -4 \n", "GO:0097023 fructose 6-phosphate aldolase activity -4 \n", "GO:0004165 delta(3)-delta(2)-enoyl-CoA isomerase activity -4 \n", "GO:0106294 NADPH oxidase H202-forming activity -4 \n", "GO:0090556 phosphatidylserine floppase activity -3 \n", "GO:0047748 cholestanetetraol 26-dehydrogenase activity -3 \n", "GO:0016290 palmitoyl-CoA hydrolase activity -3 \n", "GO:0004722 protein serine/threonine phosphatase activity -3 \n", "GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity -3 \n", "GO:0140567 membrane protein dislocase activity -3 \n", "GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) acti... -3 \n", "GO:0008458 carnitine O-octanoyltransferase activity -3 \n", "GO:0102391 decanoate-CoA ligase activity -2 \n", "GO:0047956 glycerol dehydrogenase [NADP+] activity -2 \n", "GO:0062189 anandamide 14,15 epoxidase activity -2 \n", "GO:0043262 ADP phosphatase activity -2 \n", "GO:0106347 U2 snRNA 2'-O-methyladenosine m6 methyltransfer... -2 \n", "GO:0042054 histone methyltransferase activity -2 \n", "GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phos... -2 \n", "GO:0047451 (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] d... -2 \n", "GO:0043759 methylbutanoate-CoA ligase activity -2 \n", "GO:0106156 peptidyl-lysine 4-dioxygenase activity -2 \n", "GO:0044594 17-beta-hydroxysteroid dehydrogenase (NAD+) act... -2 \n", "GO:0047376 all-trans-retinyl-palmitate hydrolase, all-tran... -2 \n", "GO:0106364 4-hydroxy-3-all-trans-hexaprenylbenzoate oxygen... -2 \n", "GO:0034480 phosphatidylcholine phospholipase C activity -2 \n", "GO:0002083 4-hydroxybenzoate decaprenyltransferase activity -2 \n", "GO:0047035 testosterone dehydrogenase (NAD+) activity -2 \n", "GO:0062188 anandamide 11,12 epoxidase activity -2 \n", "GO:0062187 anandamide 8,9 epoxidase activity -2 \n", "GO:0090554 phosphatidylcholine floppase activity -2 \n", "GO:0004317 (3R)-hydroxypalmitoyl-[acyl-carrier-protein] de... -2 \n", "GO:0051922 cholesterol sulfotransferase activity -2 \n", "GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phospha... -2 \n", "GO:0016312 inositol bisphosphate phosphatase activity -2 \n", "GO:0052848 inositol-3,5-bisdiphosphate-2,3,4,6-tetrakispho... -2 \n", "GO:0015417 ABC-type polyamine transporter activity -2 \n", "GO:0008106 alcohol dehydrogenase (NADP+) activity -2 \n", "GO:0052845 inositol-5-diphosphate-1,2,3,4,6-pentakisphosph... -2 \n", "GO:0008970 phospholipase A1 activity -2 \n", "GO:0019705 protein-cysteine S-myristoyltransferase activity -2 \n", "GO:0008693 (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] d... -2 \n", "GO:0106009 (4S)-4-hydroxy-2-oxoglutarate aldolase activity -1 \n", "GO:0102336 3-oxo-arachidoyl-CoA synthase activity -1 \n", "GO:0103026 fructose-1-phosphatase activity -1 \n", "GO:0098606 selenocystathionine gamma-lyase activity -1 \n", "GO:0102991 myristoyl-CoA hydrolase activity -1 \n", "GO:0102662 malonate-semialdehyde dehydrogenase (acetylatin... -1 \n", "GO:0102354 11-cis-retinol dehydrogenase activity -1 \n", "GO:0102149 farnesylcysteine lyase activity -1 \n", "GO:0102175 3-beta-hydroxysteroid dehydrogenase/C4-decarbox... -1 \n", "GO:0102338 3-oxo-lignoceronyl-CoA synthase activity -1 \n", "GO:0102337 3-oxo-cerotoyl-CoA synthase activity -1 \n", "GO:0106008 2-oxoglutaramate amidase activity -1 \n", "GO:0097383 dIDP phosphatase activity -1 \n", "GO:0106375 deoxynucleoside triphosphate hydrolase activity -1 \n", "GO:0106237 arachidonate 12(R)-lipoxygenase activity -1 \n", "GO:1901480 oleate transmembrane transporter activity -1 \n", "GO:0140948 histone H3K9 monomethyltransferase activity -1 \n", "GO:0140947 histone H3K9me2 methyltransferase activity -1 \n", "GO:0140945 histone H3K4 monomethyltransferase activity -1 \n", "GO:0140944 histone H4K20 monomethyltransferase activity -1 \n", "GO:0140943 histone H4K20 trimethyltransferase activity -1 \n", "GO:0140941 histone H4K20me methyltransferase activity -1 \n", "GO:0140818 mRNA 5'-phosphatase activity -1 \n", "GO:0140804 NAD+- protein-lysine ADP-ribosyltransferase act... -1 \n", "GO:0140803 NAD+- protein-cysteine ADP-ribosyltransferase a... -1 \n", "GO:0140683 histone H3K9me/H3K9me2 demethylase activity -1 \n", "GO:0140562 EGF-domain serine xylosyltransferase activity -1 \n", "GO:0140561 EGF-domain serine glucosyltransferase activity -1 \n", "GO:0106226 peptide 2-hydroxyisobutyryltransferase activity -1 \n", "GO:0140439 protein-cysteine S-stearoyltransferase activity -1 \n", "GO:0120243 2-iminopropanoate deaminase activity -1 \n", "GO:0120092 crotonyl-CoA hydratase activity -1 \n", "GO:0110153 RNA NAD-cap (NMN-forming) hydrolase activity -1 \n", "GO:0106433 O6-methyl-dGTP hydrolase activity -1 \n", "GO:0106431 N6-methyl-(d)ATP hydrolase activity -1 \n", "GO:0106399 acyl-coenzyme A diphosphatase activity -1 \n", "GO:0106386 (3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity -1 \n", "GO:0106376 2-hydroxyphytanoyl-CoA lyase activity -1 \n", "GO:0106329 L-phenylalaine oxidase activity -1 \n", "GO:0106313 methylenetetrahydrofolate reductase NADPH activity -1 \n", "GO:0106310 protein serine kinase activity -1 \n", "GO:0106301 arachidonic acid 5,6-epoxygenase activity -1 \n", "GO:0106293 NADH oxidase H202-forming activity -1 \n", "GO:0120298 peptide noradrenalinyltransferase activity -1 \n", "GO:0080079 cellobiose glucosidase activity -1 \n", "GO:0047982 homocysteine desulfhydrase activity -1 \n", "GO:0070251 pristanate-CoA ligase activity -1 \n", "GO:0036220 ITP diphosphatase activity -1 \n", "GO:0036219 GTP diphosphatase activity -1 \n", "GO:0036218 dTTP diphosphatase activity -1 \n", "GO:0036130 prostaglandin H2 endoperoxidase reductase activity -1 \n", "GO:0035870 dITP diphosphatase activity -1 \n", "GO:0035242 protein-arginine omega-N asymmetric methyltrans... -1 \n", "GO:0035241 protein-arginine omega-N monomethyltransferase ... -1 \n", "GO:0033779 5beta-cholestane-3alpha,7alpha-diol 12alpha-hyd... -1 \n", "GO:0033703 3beta-hydroxy-5beta-steroid dehydrogenase activity -1 \n", "GO:0031956 medium-chain fatty acid-CoA ligase activity -1 \n", "GO:0018820 cyanamide hydratase activity -1 \n", "GO:0016617 4-oxoproline reductase activity -1 \n", "GO:0010308 acireductone dioxygenase (Ni2+-requiring) activity -1 \n", "GO:0008983 protein-glutamate O-methyltransferase activity -1 \n", "GO:0008753 NADPH dehydrogenase (quinone) activity -1 \n", "GO:0008405 arachidonic acid 11,12-epoxygenase activity -1 \n", "GO:0008404 arachidonic acid 14,15-epoxygenase activity -1 \n", "GO:0004806 triglyceride lipase activity -1 \n", "GO:0004745 NAD-retinol dehydrogenase activity -1 \n", "GO:0004427 inorganic diphosphate phosphatase activity -1 \n", "GO:0004354 glutamate dehydrogenase (NADP+) activity -1 \n", "GO:0004336 galactosylceramidase activity -1 \n", "GO:0004180 carboxypeptidase activity -1 \n", "GO:0004052 arachidonate 12(S)-lipoxygenase activity -1 \n", "GO:0003954 NADH dehydrogenase activity -1 \n", "GO:0036221 UTP diphosphatase activity -1 \n", "GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) ac... -1 \n", "GO:0036222 XTP diphosphatase activity -1 \n", "GO:0036430 CMP kinase activity -1 \n", "GO:0062184 testosterone 16-beta-hydroxylase activity -1 \n", "GO:0062183 all-trans retinoic acid 18-hydroxylase activity -1 \n", "GO:0062182 all-trans retinoic acid 4-hydrolase activity -1 \n", "GO:0062154 N6-methyl-AMP deaminase activity -1 \n", "GO:0052596 phenethylamine:oxygen oxidoreductase (deaminati... -1 \n", "GO:0052595 aliphatic amine oxidase activity -1 \n", "GO:0050213 progesterone 5-alpha-reductase activity -1 \n", "GO:0050048 L-leucine:2-oxoglutarate aminotransferase activity -1 \n", "GO:0047995 hydroxyphenylpyruvate reductase activity -1 \n", "GO:1990002 methylglyoxal reductase (NADPH-dependent, aceto... -1 \n", "GO:0047975 guanosine phosphorylase activity -1 \n", "GO:0047935 glucose 1-dehydrogenase (NADP+) activity -1 \n", "GO:0036403 arachidonate 8(S)-lipoxygenase activity -1 \n", "GO:0047934 glucose 1-dehydrogenase (NAD+) activity -1 \n", "GO:0047844 deoxycytidine deaminase activity -1 \n", "GO:0047693 ATP diphosphatase activity -1 \n", "GO:0047638 albendazole monooxygenase activity -1 \n", "GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity -1 \n", "GO:0047378 acetylalkylglycerol acetylhydrolase activity -1 \n", "GO:0047022 7-beta-hydroxysteroid dehydrogenase (NADP+) act... -1 \n", "GO:0046899 nucleoside triphosphate adenylate kinase activity -1 \n", "GO:0043956 3-hydroxypropionyl-CoA dehydratase activity -1 \n", "GO:0043878 glyceraldehyde-3-phosphate dehydrogenase (NAD+)... -1 \n", "GO:0043273 CTPase activity -1 \n", "GO:0036431 dCMP kinase activity -1 \n", "GO:0047931 glucosamine kinase activity -1 \n", "GO:1990362 butanol dehydrogenase activity -1 \n", "GO:0016937 short-chain-acyl-CoA dehydrogenase activity 0 " ] }, "execution_count": 73, "metadata": {}, "output_type": "execute_result" } ], "source": [ "pd.set_option('display.max_rows', 1000)\n", "rhea.groupby(lbl).min(numeric_only=True).sort_values(\"closure_delta\")" ] }, { "cell_type": "code", "execution_count": 79, "id": "6eb528e5", "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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publicationsold_objectold_object_obsoleteis_deletionclosure_predicatesclosure_deltaold_object_label
subject
P224134444444
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" ], "text/plain": [ " publications old_object old_object_obsolete is_deletion \\\n", "subject \n", "P22413 4 4 4 4 \n", "\n", " closure_predicates closure_delta old_object_label \n", "subject \n", "P22413 4 4 4 " ] }, "execution_count": 79, "metadata": {}, "output_type": "execute_result" } ], "source": [ "rhea.groupby(\"subject\").count().query(\"publications > 3\")" ] }, { "cell_type": "code", "execution_count": 80, "id": "63b32587", "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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publicationssubjectold_objectold_object_obsoleteis_deletionclosure_predicatesclosure_deltaold_object_label
483[]P22413GO:0036221FalseTrue[rdfs:subClassOf, BFO:0000050]-1UTP diphosphatase activity
484[]P22413GO:0004115FalseTrue[rdfs:subClassOf, BFO:0000050]-33',5'-cyclic-AMP phosphodiesterase activity
485[]P22413GO:0036219FalseTrue[rdfs:subClassOf, BFO:0000050]-1GTP diphosphatase activity
486[]P22413GO:0047693FalseTrue[rdfs:subClassOf, BFO:0000050]-1ATP diphosphatase activity
\n", "
" ], "text/plain": [ " publications subject old_object old_object_obsolete is_deletion \\\n", "483 [] P22413 GO:0036221 False True \n", "484 [] P22413 GO:0004115 False True \n", "485 [] P22413 GO:0036219 False True \n", "486 [] P22413 GO:0047693 False True \n", "\n", " closure_predicates closure_delta \\\n", "483 [rdfs:subClassOf, BFO:0000050] -1 \n", "484 [rdfs:subClassOf, BFO:0000050] -3 \n", "485 [rdfs:subClassOf, BFO:0000050] -1 \n", "486 [rdfs:subClassOf, BFO:0000050] -1 \n", "\n", " old_object_label \n", "483 UTP diphosphatase activity \n", "484 3',5'-cyclic-AMP phosphodiesterase activity \n", "485 GTP diphosphatase activity \n", "486 ATP diphosphatase activity " ] }, "execution_count": 80, "metadata": {}, "output_type": "execute_result" } ], "source": [ "rhea.query(\"subject == 'P22413'\")" ] }, { "cell_type": "code", "execution_count": 81, "id": "21fe4286", "metadata": {}, "outputs": [ { "data": { "text/plain": [ "closure_delta -1341\n", "dtype: int64" ] }, "execution_count": 81, "metadata": {}, "output_type": "execute_result" } ], "source": [ "rhea[[\"closure_delta\"]].sum()" ] }, { "cell_type": "markdown", "id": "2a87ec34", "metadata": {}, "source": [ "## ARBA" ] }, { "cell_type": "code", "execution_count": 74, "id": "0e9ded96", "metadata": {}, "outputs": [], "source": [ "arba = analyze_iea(df, \"GO_REF:0000117\")" ] }, { "cell_type": "code", "execution_count": 84, "id": "1925d2cc", "metadata": {}, "outputs": [], "source": [ "add_labels(arba)" ] }, { "cell_type": "code", "execution_count": 85, "id": "e6f68238", "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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publicationssubjectold_objectold_object_obsoleteis_deletionclosure_predicatesclosure_deltaold_object_label
0[]Q96JM4GO:0009966NoneTrue[]-10regulation of signal transduction
1[]Q96MZ0GO:0005737NoneTrue[]-15cytoplasm
2[]P37275GO:0044271FalseTrue[rdfs:subClassOf, BFO:0000050]0cellular nitrogen compound biosynthetic process
3[]Q8TC17GO:0005737FalseTrue[rdfs:subClassOf, BFO:0000050]-15cytoplasm
4[]Q9Y5H1GO:0007399FalseTrue[rdfs:subClassOf, BFO:0000050]-6nervous system development
...........................
207[]P32745GO:0007187FalseTrue[rdfs:subClassOf, BFO:0000050]-1G protein-coupled receptor signaling pathway, ...
208[]P32745GO:0008285FalseTrue[rdfs:subClassOf, BFO:0000050]-4negative regulation of cell population prolife...
209[]P29144GO:0006508FalseTrue[rdfs:subClassOf, BFO:0000050]-1proteolysis
210[]Q9Y5G2GO:0007399FalseTrue[rdfs:subClassOf, BFO:0000050]-6nervous system development
211[]Q5TH69GO:0005794FalseTrue[rdfs:subClassOf, BFO:0000050]-1Golgi apparatus
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212 rows × 8 columns

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" ], "text/plain": [ " publications subject old_object old_object_obsolete is_deletion \\\n", "0 [] Q96JM4 GO:0009966 None True \n", "1 [] Q96MZ0 GO:0005737 None True \n", "2 [] P37275 GO:0044271 False True \n", "3 [] Q8TC17 GO:0005737 False True \n", "4 [] Q9Y5H1 GO:0007399 False True \n", ".. ... ... ... ... ... \n", "207 [] P32745 GO:0007187 False True \n", "208 [] P32745 GO:0008285 False True \n", "209 [] P29144 GO:0006508 False True \n", "210 [] Q9Y5G2 GO:0007399 False True \n", "211 [] Q5TH69 GO:0005794 False True \n", "\n", " closure_predicates closure_delta \\\n", "0 [] -10 \n", "1 [] -15 \n", "2 [rdfs:subClassOf, BFO:0000050] 0 \n", "3 [rdfs:subClassOf, BFO:0000050] -15 \n", "4 [rdfs:subClassOf, BFO:0000050] -6 \n", ".. ... ... \n", "207 [rdfs:subClassOf, BFO:0000050] -1 \n", "208 [rdfs:subClassOf, BFO:0000050] -4 \n", "209 [rdfs:subClassOf, BFO:0000050] -1 \n", "210 [rdfs:subClassOf, BFO:0000050] -6 \n", "211 [rdfs:subClassOf, BFO:0000050] -1 \n", "\n", " old_object_label \n", "0 regulation of signal transduction \n", "1 cytoplasm \n", "2 cellular nitrogen compound biosynthetic process \n", "3 cytoplasm \n", "4 nervous system development \n", ".. ... \n", "207 G protein-coupled receptor signaling pathway, ... \n", "208 negative regulation of cell population prolife... \n", "209 proteolysis \n", "210 nervous system development \n", "211 Golgi apparatus \n", "\n", "[212 rows x 8 columns]" ] }, "execution_count": 85, "metadata": {}, "output_type": "execute_result" } ], "source": [ "pd.set_option('display.max_rows', 10)\n", "arba" ] }, { "cell_type": "code", "execution_count": 82, "id": "aacc48b9", "metadata": {}, "outputs": [ { "data": { "text/plain": [ "closure_delta -1252\n", "dtype: int64" ] }, "execution_count": 82, "metadata": {}, "output_type": "execute_result" } ], "source": [ "arba[[\"closure_delta\"]].sum()" ] }, { "cell_type": "code", "execution_count": 86, "id": "09f90719", "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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is_deletionclosure_delta
old_objectold_object_label
GO:0045892negative regulation of DNA-templated transcriptionTrue-31
GO:0022625cytosolic large ribosomal subunitTrue-28
GO:0005783endoplasmic reticulumTrue-21
GO:0005634nucleusTrue-19
GO:0043162ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwayTrue-18
GO:0007080mitotic metaphase plate congressionTrue-18
GO:0006470protein dephosphorylationTrue-16
GO:1901673regulation of mitotic spindle assemblyTrue-16
GO:0005737cytoplasmTrue-15
GO:0032434regulation of proteasomal ubiquitin-dependent protein catabolic processTrue-14
GO:0006468protein phosphorylationTrue-14
GO:0005794Golgi apparatusTrue-14
GO:0016070RNA metabolic processTrue-14
GO:0046488phosphatidylinositol metabolic processTrue-14
GO:0001527microfibrilTrue-13
GO:0015012heparan sulfate proteoglycan biosynthetic processTrue-13
GO:0005828kinetochore microtubuleTrue-12
GO:0046761viral budding from plasma membraneTrue-12
GO:0098590plasma membrane regionTrue-11
GO:0097352autophagosome maturationTrue-11
GO:0016925protein sumoylationTrue-11
GO:0061952midbody abscissionTrue-11
GO:0009966regulation of signal transductionTrue-10
GO:0005886plasma membraneTrue-10
GO:0015229L-ascorbic acid transmembrane transporter activityTrue-10
GO:0031468nuclear membrane reassemblyTrue-9
GO:0043229intracellular organelleTrue-9
GO:0000776kinetochoreTrue-9
GO:0005930axonemeTrue-9
GO:0005125cytokine activityTrue-9
GO:0016020membraneTrue-8
GO:0006508proteolysisTrue-8
GO:0016567protein ubiquitinationTrue-7
GO:0001778plasma membrane repairTrue-7
GO:0110165cellular anatomical entityTrue-7
GO:0007605sensory perception of soundTrue-7
GO:0008194UDP-glycosyltransferase activityTrue-7
GO:0060548negative regulation of cell deathTrue-7
GO:0043565sequence-specific DNA bindingTrue-6
GO:0005643nuclear poreTrue-6
GO:0006281DNA repairTrue-6
GO:0016311dephosphorylationTrue-6
GO:1904930amphisome membraneTrue-6
GO:0005765lysosomal membraneTrue-6
GO:00977299+2 motile ciliumTrue-6
GO:0007399nervous system developmentTrue-6
GO:0009925basal plasma membraneTrue-5
GO:0039702viral budding via host ESCRT complexTrue-5
GO:0033554cellular response to stressTrue-5
GO:0033036macromolecule localizationTrue-5
GO:0008757S-adenosylmethionine-dependent methyltransferase activityTrue-5
GO:0046470phosphatidylcholine metabolic processTrue-5
GO:0005654nucleoplasmTrue-5
GO:0007606sensory perception of chemical stimulusTrue-5
GO:0048468cell developmentTrue-5
GO:0015250water channel activityTrue-4
GO:0008201heparin bindingTrue-4
GO:0051128regulation of cellular component organizationTrue-4
GO:0008285negative regulation of cell population proliferationTrue-4
GO:0005635nuclear envelopeTrue-4
GO:0005789endoplasmic reticulum membraneTrue-4
GO:0048583regulation of response to stimulusTrue-4
GO:0031982vesicleTrue-3
GO:0071704organic substance metabolic processTrue-3
GO:0005764lysosomeTrue-2
GO:0061459L-arginine transmembrane transporter activityTrue-2
GO:0097381photoreceptor disc membraneTrue-2
GO:0032585multivesicular body membraneTrue-2
GO:0006950response to stressTrue-2
GO:0032991protein-containing complexTrue-2
GO:0005829cytosolTrue-2
GO:0031640killing of cells of another organismTrue-2
GO:0031625ubiquitin protein ligase bindingTrue-2
GO:1902774late endosome to lysosome transportTrue-2
GO:0042802identical protein bindingTrue-2
GO:0008284positive regulation of cell population proliferationTrue-1
GO:0071705nitrogen compound transportTrue-1
GO:0071702organic substance transportTrue-1
GO:0019899enzyme bindingTrue-1
GO:0005576extracellular regionTrue-1
GO:0030496midbodyTrue-1
GO:0031996thioesterase bindingTrue-1
GO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerTrue-1
GO:0016570histone modificationTrue-1
GO:0007268chemical synaptic transmissionTrue0
GO:0044271cellular nitrogen compound biosynthetic processTrue0
GO:0070098chemokine-mediated signaling pathwayTrue0
GO:0071805potassium ion transmembrane transportTrue0
GO:0006351DNA-templated transcriptionTrue0
GO:0007155cell adhesionTrue0
GO:0006915apoptotic processTrue0
GO:0007186G protein-coupled receptor signaling pathwayTrue0
\n", "
" ], "text/plain": [ " is_deletion \\\n", "old_object old_object_label \n", "GO:0045892 negative regulation of DNA-templated transcription True \n", "GO:0022625 cytosolic large ribosomal subunit True \n", "GO:0005783 endoplasmic reticulum True \n", "GO:0005634 nucleus True \n", "GO:0043162 ubiquitin-dependent protein catabolic process v... True \n", "GO:0007080 mitotic metaphase plate congression True \n", "GO:0006470 protein dephosphorylation True \n", "GO:1901673 regulation of mitotic spindle assembly True \n", "GO:0005737 cytoplasm True \n", "GO:0032434 regulation of proteasomal ubiquitin-dependent p... True \n", "GO:0006468 protein phosphorylation True \n", "GO:0005794 Golgi apparatus True \n", "GO:0016070 RNA metabolic process True \n", "GO:0046488 phosphatidylinositol metabolic process True \n", "GO:0001527 microfibril True \n", "GO:0015012 heparan sulfate proteoglycan biosynthetic process True \n", "GO:0005828 kinetochore microtubule True \n", "GO:0046761 viral budding from plasma membrane True \n", "GO:0098590 plasma membrane region True \n", "GO:0097352 autophagosome maturation True \n", "GO:0016925 protein sumoylation True \n", "GO:0061952 midbody abscission True \n", "GO:0009966 regulation of signal transduction True \n", "GO:0005886 plasma membrane True \n", "GO:0015229 L-ascorbic acid transmembrane transporter activity True \n", "GO:0031468 nuclear membrane reassembly True \n", "GO:0043229 intracellular organelle True \n", "GO:0000776 kinetochore True \n", "GO:0005930 axoneme True \n", "GO:0005125 cytokine activity True \n", "GO:0016020 membrane True \n", "GO:0006508 proteolysis True \n", "GO:0016567 protein ubiquitination True \n", "GO:0001778 plasma membrane repair True \n", "GO:0110165 cellular anatomical entity True \n", "GO:0007605 sensory perception of sound True \n", "GO:0008194 UDP-glycosyltransferase activity True \n", "GO:0060548 negative regulation of cell death True \n", "GO:0043565 sequence-specific DNA binding True \n", "GO:0005643 nuclear pore True \n", "GO:0006281 DNA repair True \n", "GO:0016311 dephosphorylation True \n", "GO:1904930 amphisome membrane True \n", "GO:0005765 lysosomal membrane True \n", "GO:0097729 9+2 motile cilium True \n", "GO:0007399 nervous system development True \n", "GO:0009925 basal plasma membrane True \n", "GO:0039702 viral budding via host ESCRT complex True \n", "GO:0033554 cellular response to stress True \n", "GO:0033036 macromolecule localization True \n", "GO:0008757 S-adenosylmethionine-dependent methyltransferas... True \n", "GO:0046470 phosphatidylcholine metabolic process True \n", "GO:0005654 nucleoplasm True \n", "GO:0007606 sensory perception of chemical stimulus True \n", "GO:0048468 cell development True \n", "GO:0015250 water channel activity True \n", "GO:0008201 heparin binding True \n", "GO:0051128 regulation of cellular component organization True \n", "GO:0008285 negative regulation of cell population prolifer... True \n", "GO:0005635 nuclear envelope True \n", "GO:0005789 endoplasmic reticulum membrane True \n", "GO:0048583 regulation of response to stimulus True \n", "GO:0031982 vesicle True \n", "GO:0071704 organic substance metabolic process True \n", "GO:0005764 lysosome True \n", "GO:0061459 L-arginine transmembrane transporter activity True \n", "GO:0097381 photoreceptor disc membrane True \n", "GO:0032585 multivesicular body membrane True \n", "GO:0006950 response to stress True \n", "GO:0032991 protein-containing complex True \n", "GO:0005829 cytosol True \n", "GO:0031640 killing of cells of another organism True \n", "GO:0031625 ubiquitin protein ligase binding True \n", "GO:1902774 late endosome to lysosome transport True \n", "GO:0042802 identical protein binding True \n", "GO:0008284 positive regulation of cell population prolifer... True \n", "GO:0071705 nitrogen compound transport True \n", "GO:0071702 organic substance transport True \n", "GO:0019899 enzyme binding True \n", "GO:0005576 extracellular region True \n", "GO:0030496 midbody True \n", "GO:0031996 thioesterase binding True \n", "GO:0007187 G protein-coupled receptor signaling pathway, c... True \n", "GO:0016570 histone modification True \n", "GO:0007268 chemical synaptic transmission True \n", "GO:0044271 cellular nitrogen compound biosynthetic process True \n", "GO:0070098 chemokine-mediated signaling pathway True \n", "GO:0071805 potassium ion transmembrane transport True \n", "GO:0006351 DNA-templated transcription True \n", "GO:0007155 cell adhesion True \n", "GO:0006915 apoptotic process True \n", "GO:0007186 G protein-coupled receptor signaling pathway True \n", "\n", " closure_delta \n", "old_object old_object_label \n", "GO:0045892 negative regulation of DNA-templated transcription -31 \n", "GO:0022625 cytosolic large ribosomal subunit -28 \n", "GO:0005783 endoplasmic reticulum -21 \n", "GO:0005634 nucleus -19 \n", "GO:0043162 ubiquitin-dependent protein catabolic process v... -18 \n", "GO:0007080 mitotic metaphase plate congression -18 \n", "GO:0006470 protein dephosphorylation -16 \n", "GO:1901673 regulation of mitotic spindle assembly -16 \n", "GO:0005737 cytoplasm -15 \n", "GO:0032434 regulation of proteasomal ubiquitin-dependent p... -14 \n", "GO:0006468 protein phosphorylation -14 \n", "GO:0005794 Golgi apparatus -14 \n", "GO:0016070 RNA metabolic process -14 \n", "GO:0046488 phosphatidylinositol metabolic process -14 \n", "GO:0001527 microfibril -13 \n", "GO:0015012 heparan sulfate proteoglycan biosynthetic process -13 \n", "GO:0005828 kinetochore microtubule -12 \n", "GO:0046761 viral budding from plasma membrane -12 \n", "GO:0098590 plasma membrane region -11 \n", "GO:0097352 autophagosome maturation -11 \n", "GO:0016925 protein sumoylation -11 \n", "GO:0061952 midbody abscission -11 \n", "GO:0009966 regulation of signal transduction -10 \n", "GO:0005886 plasma membrane -10 \n", "GO:0015229 L-ascorbic acid transmembrane transporter activity -10 \n", "GO:0031468 nuclear membrane reassembly -9 \n", "GO:0043229 intracellular organelle -9 \n", "GO:0000776 kinetochore -9 \n", "GO:0005930 axoneme -9 \n", "GO:0005125 cytokine activity -9 \n", "GO:0016020 membrane -8 \n", "GO:0006508 proteolysis -8 \n", "GO:0016567 protein ubiquitination -7 \n", "GO:0001778 plasma membrane repair -7 \n", "GO:0110165 cellular anatomical entity -7 \n", "GO:0007605 sensory perception of sound -7 \n", "GO:0008194 UDP-glycosyltransferase activity -7 \n", "GO:0060548 negative regulation of cell death -7 \n", "GO:0043565 sequence-specific DNA binding -6 \n", "GO:0005643 nuclear pore -6 \n", "GO:0006281 DNA repair -6 \n", "GO:0016311 dephosphorylation -6 \n", "GO:1904930 amphisome membrane -6 \n", "GO:0005765 lysosomal membrane -6 \n", "GO:0097729 9+2 motile cilium -6 \n", "GO:0007399 nervous system development -6 \n", "GO:0009925 basal plasma membrane -5 \n", "GO:0039702 viral budding via host ESCRT complex -5 \n", "GO:0033554 cellular response to stress -5 \n", "GO:0033036 macromolecule localization -5 \n", "GO:0008757 S-adenosylmethionine-dependent methyltransferas... -5 \n", "GO:0046470 phosphatidylcholine metabolic process -5 \n", "GO:0005654 nucleoplasm -5 \n", "GO:0007606 sensory perception of chemical stimulus -5 \n", "GO:0048468 cell development -5 \n", "GO:0015250 water channel activity -4 \n", "GO:0008201 heparin binding -4 \n", "GO:0051128 regulation of cellular component organization -4 \n", "GO:0008285 negative regulation of cell population prolifer... -4 \n", "GO:0005635 nuclear envelope -4 \n", "GO:0005789 endoplasmic reticulum membrane -4 \n", "GO:0048583 regulation of response to stimulus -4 \n", "GO:0031982 vesicle -3 \n", "GO:0071704 organic substance metabolic process -3 \n", "GO:0005764 lysosome -2 \n", "GO:0061459 L-arginine transmembrane transporter activity -2 \n", "GO:0097381 photoreceptor disc membrane -2 \n", "GO:0032585 multivesicular body membrane -2 \n", "GO:0006950 response to stress -2 \n", "GO:0032991 protein-containing complex -2 \n", "GO:0005829 cytosol -2 \n", "GO:0031640 killing of cells of another organism -2 \n", "GO:0031625 ubiquitin protein ligase binding -2 \n", "GO:1902774 late endosome to lysosome transport -2 \n", "GO:0042802 identical protein binding -2 \n", "GO:0008284 positive regulation of cell population prolifer... -1 \n", "GO:0071705 nitrogen compound transport -1 \n", "GO:0071702 organic substance transport -1 \n", "GO:0019899 enzyme binding -1 \n", "GO:0005576 extracellular region -1 \n", "GO:0030496 midbody -1 \n", "GO:0031996 thioesterase binding -1 \n", "GO:0007187 G protein-coupled receptor signaling pathway, c... -1 \n", "GO:0016570 histone modification -1 \n", "GO:0007268 chemical synaptic transmission 0 \n", "GO:0044271 cellular nitrogen compound biosynthetic process 0 \n", "GO:0070098 chemokine-mediated signaling pathway 0 \n", "GO:0071805 potassium ion transmembrane transport 0 \n", "GO:0006351 DNA-templated transcription 0 \n", "GO:0007155 cell adhesion 0 \n", "GO:0006915 apoptotic process 0 \n", "GO:0007186 G protein-coupled receptor signaling pathway 0 " ] }, "execution_count": 86, "metadata": {}, "output_type": "execute_result" } ], "source": [ "pd.set_option('display.max_rows', 1000)\n", "arba.groupby(lbl).min(numeric_only=True).sort_values(\"closure_delta\")" ] }, { "cell_type": "markdown", "id": "5d77c6cd", "metadata": {}, "source": [ "## All IEAs" ] }, { "cell_type": "code", "execution_count": 87, "id": "0b25710f", "metadata": {}, "outputs": [], "source": [ "# this takes some time....\n", "dfs_by_ref = {}\n", "for goref in gorefs:\n", " print(goref)\n", " dfs_by_ref[goref] = analyze_iea(df, goref)" ] }, { "cell_type": "code", "execution_count": 92, "id": "043c1aff", "metadata": {}, "outputs": [], "source": [ "for k, df in dfs_by_ref.items():\n", " df[\"method\"] = k" ] }, { "cell_type": "code", "execution_count": 93, "id": "99a5c84d", "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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Q96EH8 GO:0016567 False True \n", "120 [] Q06203 GO:0006189 False True \n", "121 [] Q16831 GO:0044206 False True \n", "122 [] Q16719 GO:0097053 False True \n", "123 [] Q9H0C5 GO:0016567 False True \n", "124 [] O14508 GO:0016567 False True \n", "125 [] Q6YFQ2 GO:0006119 False True \n", "126 [] Q8TBF5 GO:0006506 False True \n", "127 [] Q13907 GO:0050992 False True \n", "128 [] Q02928 GO:0031408 False True \n", "129 [] Q8TEB7 GO:0016567 False True \n", "130 [] P05089 GO:0000050 False True \n", "131 [] Q8N5Z0 GO:0033512 False True \n", "132 [] Q8NHY2 GO:0016567 False True \n", "133 [] P49641 GO:0006486 False True \n", "134 [] P10746 GO:0006782 False True \n", "135 [] A8MWK0 GO:0006636 False True \n", "136 [] Q9H2A2 GO:0097053 False True \n", "137 [] Q8WXH5 GO:0016567 False True \n", "138 [] O43255 GO:0016567 False True \n", "139 [] Q9NRZ7 GO:0016024 False True \n", "140 [] Q5XUX0 GO:0016567 False True \n", "141 [] Q9UKM7 GO:0006486 False True \n", "142 [] P37058 GO:0061370 False True \n", "143 [] O00763 GO:2001295 False True \n", "144 [] Q5T197 GO:0016567 False True \n", "145 [] O14543 GO:0016567 False True \n", "146 [] Q14409 GO:0019563 False True \n", "147 [] Q9HBH5 GO:0042572 False True \n", "148 [] Q16706 GO:0006486 False True \n", "149 [] P52849 GO:0030210 False True \n", "150 [] O14732 GO:0006021 False True \n", "151 [] Q9H477 GO:0019303 False True \n", "152 [] Q12882 GO:0019483 False True \n", "153 [] Q5XPI4 GO:0016567 False True \n", "154 [] Q96NU7 GO:0019556 False True \n", "155 [] Q96NU7 GO:0019557 False True \n", "156 [] P78540 GO:0000050 False True \n", "157 [] Q96S21 GO:0016567 False True \n", "158 [] P22570 GO:0008203 False True \n", "159 [] Q8IY47 GO:0016567 False True \n", "160 [] O60513 GO:0006486 False True \n", "161 [] Q6P050 GO:0016567 False True \n", "162 [] Q86WB0 GO:0016567 False True \n", "163 [] Q13946 GO:0006198 False True \n", "164 [] Q9UDR5 GO:0033512 False True \n", "165 [] Q01433 GO:0032264 False True \n", "166 [] Q9H3R1 GO:0030210 False True \n", "167 [] Q08499 GO:0006198 False True \n", "168 [] Q9UK99 GO:0016567 False True \n", "169 [] P50336 GO:0006782 False True \n", "170 [] Q9NXK8 GO:0016567 False True \n", "171 [] Q9NV06 GO:0016567 False True \n", "172 [] Q5T6F0 GO:0016567 False True \n", "173 [] Q9NPZ5 GO:0006486 False True \n", "174 [] Q6ZS86 GO:0019563 False True \n", "175 [] Q8IWU9 GO:0042427 False True \n", "176 [] Q14410 GO:0019563 False True \n", "177 [] P04818 GO:0006235 False True \n", "178 [] Q8IWR1 GO:0016567 False True \n", "179 [] O60512 GO:0006486 False True \n", "180 [] P42357 GO:0019556 False True \n", "181 [] P42357 GO:0019557 False True \n", "182 [] Q9NRD1 GO:0016567 False True \n", "183 [] Q9NYL5 GO:0006707 False True \n", "184 [] O75159 GO:0016567 False True \n", "185 [] Q9UJV3 GO:0016567 False True \n", "186 [] Q9NUQ2 GO:0016024 False True \n", "187 [] P16442 GO:0006486 False True \n", "188 [] Q9UBQ6 GO:0015012 False True \n", "189 [] P33260 GO:0042572 False True \n", "190 [] P61962 GO:0016567 False True \n", "191 [] Q9UHE5 GO:0006749 False True \n", "192 [] Q86Y38 GO:0030206 False True \n", "193 [] P08684 GO:0008203 False True \n", "194 [] Q8WXK3 GO:0016567 False True \n", "195 [] Q92935 GO:0006486 False True \n", "196 [] Q9BSL1 GO:0016567 False True \n", "197 [] Q8N806 GO:0016567 False True \n", "198 [] Q6PID8 GO:0016567 False True \n", "199 [] O14512 GO:0016567 False True \n", "200 [] P54886 GO:0055129 False True \n", "201 [] Q9NPI5 GO:0009435 False True \n", "202 [] Q9HB03 GO:0006636 False True \n", "203 [] Q7Z6M2 GO:0016567 False True \n", "204 [] Q8NC69 GO:0016567 False True \n", "205 [] Q6ZNI0 GO:0006486 False True \n", "206 [] P20711 GO:0042416 False True \n", "207 [] Q8TBE9 GO:0006045 False True \n", "208 [] Q66K89 GO:0016567 False True \n", "209 [] Q9BZQ6 GO:0006486 False True \n", "210 [] Q495W5 GO:0006486 False True \n", "211 [] O95954 GO:0019556 False True \n", "212 [] O95954 GO:0019557 False True \n", "213 [] P11712 GO:0008203 False True \n", "214 [] Q6P3W2 GO:0017183 False True \n", "215 [] Q8WXJ9 GO:0016567 False True \n", "216 [] Q7L622 GO:0016567 False True \n", "217 [] Q8N4N3 GO:0016567 False True \n", "218 [] O60218 GO:0042572 False True \n", "219 [] Q12829 GO:0016567 False True \n", "220 [] Q9NWZ5 GO:0044206 False True \n", "221 [] Q9NWZ5 GO:0044211 False True \n", "222 [] P05091 GO:0006068 False True \n", "223 [] Q13825 GO:0006552 False True \n", "224 [] Q6PJ21 GO:0016567 False True \n", "225 [] Q93088 GO:0006579 False True \n", "226 [] P24298 GO:0042853 False True \n", "227 [] Q96L58 GO:0030206 False True \n", "228 [] Q96L58 GO:0015012 False True \n", "229 [] Q8N5D0 GO:0016567 False True \n", "230 [] Q96JK2 GO:0016567 False True \n", "231 [] Q9HBI6 GO:0031408 False True \n", "232 [] Q5T4S7 GO:0016567 False True \n", "233 [] P27815 GO:0006198 False True \n", "234 [] Q8NE62 GO:0019285 False True \n", "235 [] Q03393 GO:0006729 False True \n", "236 [] Q96JP0 GO:0016567 False True \n", "237 [] Q8NEA9 GO:0016567 False True \n", "238 [] Q9NWX5 GO:0016567 False True \n", "239 [] Q6JEL2 GO:0016567 False True \n", "240 [] Q92947 GO:0006568 False True \n", "241 [] Q53H12 GO:0046486 False True \n", "242 [] Q5TAQ9 GO:0016567 False True \n", "243 [] Q05516 GO:0016567 False True \n", "244 [] Q9UK73 GO:0016567 False True \n", "245 [] Q96L50 GO:0016567 False True \n", "246 [] P30837 GO:0006068 False True \n", "247 [] Q9UKU7 GO:0006574 False True \n", "248 [] Q9UJM8 GO:0006545 False True \n", "249 [] Q5VXH4 GO:0016567 False True \n", "250 [] Q6IQ16 GO:0016567 False True \n", "251 [] Q9Y2T3 GO:0006147 False True \n", "252 [] Q9HCL2 GO:0016024 False True \n", "253 [] A5PLL7 GO:0006631 False True \n", "254 [] Q15345 GO:0016567 False True \n", "255 [] P17812 GO:0044210 False True \n", "256 [] Q9Y223 GO:0006045 False True \n", "257 [] P10635 GO:0008203 False True \n", "258 [] Q07343 GO:0006198 False True \n", "259 [] P00439 GO:0006559 False True \n", "260 [] Q9H9P5 GO:0016567 False True \n", "261 [] P32754 GO:0006559 False True \n", "262 [] P46019 GO:0005977 False True \n", "263 [] O94766 GO:0006486 False True \n", "264 [] Q4G163 GO:0016567 False True \n", "265 [] P31350 GO:0006260 False True \n", "266 [] Q9Y5Q0 GO:0006665 False True \n", "267 [] O60658 GO:0006198 False True \n", "268 [] Q9Y2U9 GO:0016567 False True \n", "269 [] Q53GQ0 GO:0006703 False True \n", "270 [] Q53GQ0 GO:0006633 False True \n", "271 [] C9JR72 GO:0016567 False True \n", "272 [] Q9H765 GO:0016567 False True \n", "273 [] Q6NUI2 GO:0016024 False True \n", "274 [] Q08493 GO:0006198 False True \n", "275 [] Q08477 GO:0019369 False True \n", "276 [] O95045 GO:0044206 False True \n", "277 [] O94788 GO:0042572 False True \n", "278 [] Q8WWF5 GO:0016567 False True \n", "279 [] P52848 GO:0030210 False True \n", "280 [] Q8N9L9 GO:0006633 False True \n", "281 [] Q92523 GO:0006635 False True \n", "282 [] A8MQ27 GO:0016567 False True \n", "283 [] Q86UL3 GO:0016024 False True \n", "284 [] Q8NFW8 GO:0006054 False True \n", "285 [] Q9C026 GO:0016567 False True \n", "286 [] Q9Y233 GO:0046069 False True \n", "287 [] Q9Y233 GO:0006198 False True \n", "288 [] Q86YJ5 GO:0016567 False True \n", "289 [] Q9NRZ5 GO:0016024 False True \n", "290 [] Q13191 GO:0016567 False True \n", "291 [] P43353 GO:0006068 False True \n", "292 [] P46020 GO:0005977 False True \n", "293 [] P0DUQ2 GO:0016567 False True \n", "294 [] Q6YP21 GO:0097053 False True \n", "295 [] Q93100 GO:0005977 False True \n", "296 [] Q58WW2 GO:0016567 False True \n", "297 [] Q9P2E8 GO:0016567 False True \n", "298 [] Q6ZVZ8 GO:0016567 False True \n", "299 [] Q8NDV1 GO:0006486 False True \n", "300 [] Q96G25 GO:0016567 False True \n", "301 [] P05177 GO:0008203 False True \n", "302 [] Q9H832 GO:0016567 False True \n", "303 [] Q13085 GO:2001295 False True \n", "304 [] Q96K19 GO:0016567 False True \n", "305 [] Q9NPC3 GO:0016567 False True \n", "306 [] Q5T447 GO:0016567 False True \n", "307 [] O95263 GO:0006198 False True \n", "308 [] O60476 GO:0006486 False True \n", "309 [] O95864 GO:0006636 False True \n", "310 [] Q9UBX8 GO:0006486 False True \n", "311 [] P30793 GO:0035998 False True \n", "312 [] P29218 GO:0006021 False True \n", "313 [] Q9UL01 GO:0030206 False True \n", "314 [] Q9UL01 GO:0015012 False True \n", "315 [] O14544 GO:0016567 False True \n", "316 [] Q9NYP7 GO:0006636 False True \n", "317 [] Q16773 GO:0097053 False True \n", "318 [] P49419 GO:0019285 False True \n", "319 [] Q8NA82 GO:0016567 False True \n", "320 [] P48637 GO:0006750 False True \n", "321 [] P41226 GO:0016567 False True \n", "322 [] Q8WXI3 GO:0016567 False True \n", "323 [] Q8NC42 GO:0016567 False True \n", "\n", " closure_predicates closure_delta method \n", "0 [rdfs:subClassOf, BFO:0000050] -2 GO_REF:0000041 \n", "1 [rdfs:subClassOf, BFO:0000050] -2 GO_REF:0000041 \n", "2 [rdfs:subClassOf, BFO:0000050] -4 GO_REF:0000041 \n", "3 [rdfs:subClassOf, BFO:0000050] -1 GO_REF:0000041 \n", "4 [rdfs:subClassOf, BFO:0000050] -3 GO_REF:0000041 \n", "5 [rdfs:subClassOf, BFO:0000050] -5 GO_REF:0000041 \n", "6 [rdfs:subClassOf, BFO:0000050] -12 GO_REF:0000041 \n", "7 [rdfs:subClassOf, BFO:0000050] -2 GO_REF:0000041 \n", "8 [rdfs:subClassOf, BFO:0000050] -12 GO_REF:0000041 \n", "9 [rdfs:subClassOf, BFO:0000050] -5 GO_REF:0000041 \n", "10 [rdfs:subClassOf, BFO:0000050] -13 GO_REF:0000041 \n", "11 [rdfs:subClassOf, BFO:0000050] -11 GO_REF:0000041 \n", "12 [rdfs:subClassOf, BFO:0000050] -8 GO_REF:0000041 \n", "13 [rdfs:subClassOf, BFO:0000050] -5 GO_REF:0000041 \n", "14 [rdfs:subClassOf, BFO:0000050] -5 GO_REF:0000041 \n", "15 [rdfs:subClassOf, BFO:0000050] -1 GO_REF:0000041 \n", "16 [rdfs:subClassOf, BFO:0000050] -5 GO_REF:0000041 \n", "17 [rdfs:subClassOf, BFO:0000050] -12 GO_REF:0000041 \n", "18 [rdfs:subClassOf, BFO:0000050] -12 GO_REF:0000041 \n", "19 [rdfs:subClassOf, BFO:0000050] -14 GO_REF:0000041 \n", "20 [rdfs:subClassOf, BFO:0000050] -12 GO_REF:0000041 \n", "21 [rdfs:subClassOf, BFO:0000050] -3 GO_REF:0000041 \n", "22 [rdfs:subClassOf, BFO:0000050] -7 GO_REF:0000041 \n", "23 [rdfs:subClassOf, BFO:0000050] -2 GO_REF:0000041 \n", "24 [rdfs:subClassOf, BFO:0000050] -6 GO_REF:0000041 \n", "25 [rdfs:subClassOf, BFO:0000050] -21 GO_REF:0000041 \n", "26 [rdfs:subClassOf, BFO:0000050] -2 GO_REF:0000041 \n", "27 [rdfs:subClassOf, BFO:0000050] -4 GO_REF:0000041 \n", "28 [rdfs:subClassOf, BFO:0000050] -2 GO_REF:0000041 \n", "29 [rdfs:subClassOf, BFO:0000050] -5 GO_REF:0000041 \n", "30 [rdfs:subClassOf, BFO:0000050] -5 GO_REF:0000041 \n", "31 [rdfs:subClassOf, BFO:0000050] -9 GO_REF:0000041 \n", "32 [rdfs:subClassOf, BFO:0000050] -12 GO_REF:0000041 \n", "33 [rdfs:subClassOf, BFO:0000050] -3 GO_REF:0000041 \n", "34 [rdfs:subClassOf, BFO:0000050] -7 GO_REF:0000041 \n", "35 [rdfs:subClassOf, BFO:0000050] -5 GO_REF:0000041 \n", "36 [rdfs:subClassOf, BFO:0000050] -9 GO_REF:0000041 \n", "37 [rdfs:subClassOf, BFO:0000050] -5 GO_REF:0000041 \n", "38 [rdfs:subClassOf, BFO:0000050] -28 GO_REF:0000041 \n", "39 [rdfs:subClassOf, BFO:0000050] -2 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GO_REF:0000041 \n", "74 [rdfs:subClassOf, BFO:0000050] -9 GO_REF:0000041 \n", "75 [rdfs:subClassOf, BFO:0000050] -5 GO_REF:0000041 \n", "76 [rdfs:subClassOf, BFO:0000050] -12 GO_REF:0000041 \n", "77 [rdfs:subClassOf, BFO:0000050] -12 GO_REF:0000041 \n", "78 [rdfs:subClassOf, BFO:0000050] -2 GO_REF:0000041 \n", "79 [rdfs:subClassOf, BFO:0000050] -12 GO_REF:0000041 \n", "80 [rdfs:subClassOf, BFO:0000050] -14 GO_REF:0000041 \n", "81 [rdfs:subClassOf, BFO:0000050] -12 GO_REF:0000041 \n", "82 [rdfs:subClassOf, BFO:0000050] -2 GO_REF:0000041 \n", "83 [rdfs:subClassOf, BFO:0000050] -12 GO_REF:0000041 \n", "84 [rdfs:subClassOf, BFO:0000050] -5 GO_REF:0000041 \n", "85 [rdfs:subClassOf, BFO:0000050] -12 GO_REF:0000041 \n", "86 [rdfs:subClassOf, BFO:0000050] -14 GO_REF:0000041 \n", "87 [rdfs:subClassOf, BFO:0000050] -12 GO_REF:0000041 \n", "88 [rdfs:subClassOf, BFO:0000050] -9 GO_REF:0000041 \n", "89 [rdfs:subClassOf, BFO:0000050] -2 GO_REF:0000041 \n", "90 [rdfs:subClassOf, BFO:0000050] -2 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publicationssubjectold_objectold_object_obsoleteis_deletionclosure_predicatesclosure_deltamethodold_object_label
0[]Q53EU6GO:0016024FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041CDP-diacylglycerol biosynthetic process
1[]Q5VZY2GO:0006644FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041phospholipid metabolic process
2[]P10632GO:0042572FalseTrue[rdfs:subClassOf, BFO:0000050]-4GO_REF:0000041retinol metabolic process
3[]Q9NXB9GO:0006636FalseTrue[rdfs:subClassOf, BFO:0000050]-1GO_REF:0000041unsaturated fatty acid biosynthetic process
4[]Q969V5GO:0016925FalseTrue[rdfs:subClassOf, BFO:0000050]-3GO_REF:0000041protein sumoylation
5[]Q9P2W7GO:0006486FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein glycosylation
6[]A6NK59GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
7[]Q9H1B5GO:0030206FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041chondroitin sulfate biosynthetic process
8[]Q693B1GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
9[]O60927GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
10[]Q8WV16GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-13GO_REF:0000041protein ubiquitination
11[]Q9UK23GO:0006486FalseTrue[rdfs:subClassOf, BFO:0000050]-11GO_REF:0000041protein glycosylation
12[]Q9HAY6GO:0042572FalseTrue[rdfs:subClassOf, BFO:0000050]-8GO_REF:0000041retinol metabolic process
13[]P30038GO:0010133FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041proline catabolic process to glutamate
14[]P20815GO:0042572FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041retinol metabolic process
15[]P11172GO:0044205FalseTrue[rdfs:subClassOf, BFO:0000050]-1GO_REF:0000041'de novo' UMP biosynthetic process
16[]Q9H920GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
17[]Q8N9I9GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
18[]Q8TD30GO:0042853FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041L-alanine catabolic process
19[]P43304GO:0019563FalseTrue[rdfs:subClassOf, BFO:0000050]-14GO_REF:0000041glycerol catabolic process
20[]Q8WXH6GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
21[]Q9NQC1GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-3GO_REF:0000041protein ubiquitination
22[]Q15370GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-7GO_REF:0000041protein ubiquitination
23[]P22557GO:0006782FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041protoporphyrinogen IX biosynthetic process
24[]P08243GO:0070981FalseTrue[rdfs:subClassOf, BFO:0000050]-6GO_REF:0000041L-asparagine biosynthetic process
25[]P36957GO:0033512FalseTrue[rdfs:subClassOf, BFO:0000050]-21GO_REF:0000041L-lysine catabolic process to acetyl-CoA via s...
26[]P13716GO:0006782FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041protoporphyrinogen IX biosynthetic process
27[]P47895GO:0042572FalseTrue[rdfs:subClassOf, BFO:0000050]-4GO_REF:0000041retinol metabolic process
28[]Q9NWM0GO:0046208FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041spermine catabolic process
29[]Q8N7A1GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
30[]Q4G0X4GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
31[]P33908GO:0006486FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041protein glycosylation
32[]Q8WXK1GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
33[]O00635GO:0016925FalseTrue[rdfs:subClassOf, BFO:0000050]-3GO_REF:0000041protein sumoylation
34[]Q9UI17GO:0006579FalseTrue[rdfs:subClassOf, BFO:0000050]-7GO_REF:0000041amino-acid betaine catabolic process
35[]Q9BQ90GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
36[]P48448GO:0006068FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041ethanol catabolic process
37[]Q12834GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
38[]Q13011GO:0006635FalseTrue[rdfs:subClassOf, BFO:0000050]-28GO_REF:0000041fatty acid beta-oxidation
39[]P08397GO:0006782FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041protoporphyrinogen IX biosynthetic process
40[]P30566GO:0006189FalseTrue[rdfs:subClassOf, BFO:0000050]-3GO_REF:0000041'de novo' IMP biosynthetic process
41[]Q96NS5GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
42[]A6NNE9GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-13GO_REF:0000041protein ubiquitination
43[]Q8NEB5GO:0006644FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041phospholipid metabolic process
44[]P06132GO:0006782FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041protoporphyrinogen IX biosynthetic process
45[]P32189GO:0019563FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041glycerol catabolic process
46[]Q86XS8GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
47[]Q9BSK4GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
48[]P00352GO:0042572FalseTrue[rdfs:subClassOf, BFO:0000050]-8GO_REF:0000041retinol metabolic process
49[]Q9Y315GO:0046386FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041deoxyribose phosphate catabolic process
50[]P04181GO:0055129FalseTrue[rdfs:subClassOf, BFO:0000050]-16GO_REF:0000041L-proline biosynthetic process
51[]Q6UWP2GO:0006703FalseTrue[rdfs:subClassOf, BFO:0000050]-8GO_REF:0000041estrogen biosynthetic process
52[]P24462GO:0042572FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041retinol metabolic process
53[]Q92781GO:0042572FalseTrue[rdfs:subClassOf, BFO:0000050]-10GO_REF:0000041retinol metabolic process
54[]Q15751GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-11GO_REF:0000041protein ubiquitination
55[]Q9NRJ4GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-13GO_REF:0000041protein ubiquitination
56[]Q92624GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
57[]Q9BY49GO:0006633FalseTrue[rdfs:subClassOf, BFO:0000050]-14GO_REF:0000041fatty acid biosynthetic process
58[]Q96M94GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
59[]Q96N76GO:0019556FalseTrue[rdfs:subClassOf, BFO:0000050]-8GO_REF:0000041histidine catabolic process to glutamate and f...
60[]Q96N76GO:0019557FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041histidine catabolic process to glutamate and f...
61[]Q6UWP7GO:0016024FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041CDP-diacylglycerol biosynthetic process
62[]Q9NXF7GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-13GO_REF:0000041protein ubiquitination
63[]Q9BR09GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
64[]Q8NBN7GO:0042572FalseTrue[rdfs:subClassOf, BFO:0000050]0GO_REF:0000041retinol metabolic process
65[]Q6GTS8GO:0006631FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041fatty acid metabolic process
66[]Q9H1B7GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
67[]Q5VVX9GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-13GO_REF:0000041protein ubiquitination
68[]P55263GO:0044209FalseTrue[rdfs:subClassOf, BFO:0000050]-1GO_REF:0000041AMP salvage
69[]Q9NP56GO:0006198FalseTrue[rdfs:subClassOf, BFO:0000050]-46GO_REF:0000041cAMP catabolic process
70[]P20132GO:0006094FalseTrue[rdfs:subClassOf, BFO:0000050]-8GO_REF:0000041gluconeogenesis
71[]Q02127GO:0044205FalseTrue[rdfs:subClassOf, BFO:0000050]-11GO_REF:0000041'de novo' UMP biosynthetic process
72[]Q5QP82GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-13GO_REF:0000041protein ubiquitination
73[]Q99943GO:0016024FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041CDP-diacylglycerol biosynthetic process
74[]Q9Y4D8GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041protein ubiquitination
75[]Q16394GO:0006486FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein glycosylation
76[]Q7L273GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
77[]P49189GO:0045329FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041carnitine biosynthetic process
78[]P11086GO:0042418FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041epinephrine biosynthetic process
79[]Q9UKT4GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
80[]P50416GO:0006635FalseTrue[rdfs:subClassOf, BFO:0000050]-14GO_REF:0000041fatty acid beta-oxidation
81[]P0C0E4GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
82[]P13196GO:0006782FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041protoporphyrinogen IX biosynthetic process
83[]Q8N5D6GO:0006486FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein glycosylation
84[]Q8IUQ4GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
85[]Q9BUZ4GO:0043161FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041proteasome-mediated ubiquitin-dependent protei...
86[]Q8TCG5GO:0006635FalseTrue[rdfs:subClassOf, BFO:0000050]-14GO_REF:0000041fatty acid beta-oxidation
87[]Q99618GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
88[]Q9NSE2GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041protein ubiquitination
89[]Q9BXS1GO:0050992FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041dimethylallyl diphosphate biosynthetic process
90[]P14324GO:0033384FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041geranyl diphosphate biosynthetic process
91[]Q9GZR1GO:0016925FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041protein sumoylation
92[]Q6TDP4GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
93[]Q99685GO:0019433FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041triglyceride catabolic process
94[]O15524GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041protein ubiquitination
95[]Q8TEB1GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
96[]O60909GO:0006486FalseTrue[rdfs:subClassOf, BFO:0000050]-17GO_REF:0000041protein glycosylation
97[]O76074GO:0046069FalseTrue[rdfs:subClassOf, BFO:0000050]-46GO_REF:0000041cGMP catabolic process
98[]P21673GO:0009447FalseTrue[rdfs:subClassOf, BFO:0000050]-8GO_REF:0000041putrescine catabolic process
99[]O15120GO:0016024FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041CDP-diacylglycerol biosynthetic process
100[]Q9NWW6GO:0009435FalseTrue[rdfs:subClassOf, BFO:0000050]-18GO_REF:0000041NAD biosynthetic process
101[]Q8TBB1GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
102[]Q8WYK0GO:0006631FalseTrue[rdfs:subClassOf, BFO:0000050]-7GO_REF:0000041fatty acid metabolic process
103[]Q9H672GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
104[]O95749GO:0033384FalseTrue[rdfs:subClassOf, BFO:0000050]-10GO_REF:0000041geranyl diphosphate biosynthetic process
105[]O95749GO:0033386FalseTrue[rdfs:subClassOf, BFO:0000050]-10GO_REF:0000041geranylgeranyl diphosphate biosynthetic process
106[]O95749GO:0045337FalseTrue[rdfs:subClassOf, BFO:0000050]-10GO_REF:0000041farnesyl diphosphate biosynthetic process
107[]Q8TB52GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-13GO_REF:0000041protein ubiquitination
108[]Q9Y4B6GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-3GO_REF:0000041protein ubiquitination
109[]P04424GO:0000050FalseTrue[rdfs:subClassOf, BFO:0000050]-6GO_REF:0000041urea cycle
110[]P23109GO:0032264FalseTrue[rdfs:subClassOf, BFO:0000050]-1GO_REF:0000041IMP salvage
111[]Q9Y575GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
112[]Q5H9S7GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-13GO_REF:0000041protein ubiquitination
113[]O95803GO:0030210FalseTrue[rdfs:subClassOf, BFO:0000050]-7GO_REF:0000041heparin biosynthetic process
114[]P49675GO:0008203FalseTrue[rdfs:subClassOf, BFO:0000050]-6GO_REF:0000041cholesterol metabolic process
115[]Q9NRF8GO:0044210FalseTrue[rdfs:subClassOf, BFO:0000050]-1GO_REF:0000041'de novo' CTP biosynthetic process
116[]Q8NCN4GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-7GO_REF:0000041protein ubiquitination
117[]Q01432GO:0032264FalseTrue[rdfs:subClassOf, BFO:0000050]-6GO_REF:0000041IMP salvage
118[]Q86XP0GO:0006631FalseTrue[rdfs:subClassOf, BFO:0000050]-6GO_REF:0000041fatty acid metabolic process
119[]Q96EH8GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
120[]Q06203GO:0006189FalseTrue[rdfs:subClassOf, BFO:0000050]-3GO_REF:0000041'de novo' IMP biosynthetic process
121[]Q16831GO:0044206FalseTrue[rdfs:subClassOf, BFO:0000050]-29GO_REF:0000041UMP salvage
122[]Q16719GO:0097053FalseTrue[rdfs:subClassOf, BFO:0000050]-3GO_REF:0000041L-kynurenine catabolic process
123[]Q9H0C5GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
124[]O14508GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041protein ubiquitination
125[]Q6YFQ2GO:0006119FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041oxidative phosphorylation
126[]Q8TBF5GO:0006506FalseTrue[rdfs:subClassOf, BFO:0000050]-46GO_REF:0000041GPI anchor biosynthetic process
127[]Q13907GO:0050992FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041dimethylallyl diphosphate biosynthetic process
128[]Q02928GO:0031408FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041oxylipin biosynthetic process
129[]Q8TEB7GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
130[]P05089GO:0000050FalseTrue[rdfs:subClassOf, BFO:0000050]-10GO_REF:0000041urea cycle
131[]Q8N5Z0GO:0033512FalseTrue[rdfs:subClassOf, BFO:0000050]-40GO_REF:0000041L-lysine catabolic process to acetyl-CoA via s...
132[]Q8NHY2GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
133[]P49641GO:0006486FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041protein glycosylation
134[]P10746GO:0006782FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041protoporphyrinogen IX biosynthetic process
135[]A8MWK0GO:0006636FalseTrue[rdfs:subClassOf, BFO:0000050]-20GO_REF:0000041unsaturated fatty acid biosynthetic process
136[]Q9H2A2GO:0097053FalseTrue[rdfs:subClassOf, BFO:0000050]-23GO_REF:0000041L-kynurenine catabolic process
137[]Q8WXH5GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041protein ubiquitination
138[]O43255GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
139[]Q9NRZ7GO:0016024FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041CDP-diacylglycerol biosynthetic process
140[]Q5XUX0GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
141[]Q9UKM7GO:0006486FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041protein glycosylation
142[]P37058GO:0061370FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041testosterone biosynthetic process
143[]O00763GO:2001295FalseTrue[rdfs:subClassOf, BFO:0000050]-24GO_REF:0000041malonyl-CoA biosynthetic process
144[]Q5T197GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
145[]O14543GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041protein ubiquitination
146[]Q14409GO:0019563FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041glycerol catabolic process
147[]Q9HBH5GO:0042572FalseTrue[rdfs:subClassOf, BFO:0000050]0GO_REF:0000041retinol metabolic process
148[]Q16706GO:0006486FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041protein glycosylation
149[]P52849GO:0030210FalseTrue[rdfs:subClassOf, BFO:0000050]-7GO_REF:0000041heparin biosynthetic process
150[]O14732GO:0006021FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041inositol biosynthetic process
151[]Q9H477GO:0019303FalseTrue[rdfs:subClassOf, BFO:0000050]-10GO_REF:0000041D-ribose catabolic process
152[]Q12882GO:0019483FalseTrue[rdfs:subClassOf, BFO:0000050]-14GO_REF:0000041beta-alanine biosynthetic process
153[]Q5XPI4GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
154[]Q96NU7GO:0019556FalseTrue[rdfs:subClassOf, BFO:0000050]-8GO_REF:0000041histidine catabolic process to glutamate and f...
155[]Q96NU7GO:0019557FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041histidine catabolic process to glutamate and f...
156[]P78540GO:0000050FalseTrue[rdfs:subClassOf, BFO:0000050]-7GO_REF:0000041urea cycle
157[]Q96S21GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
158[]P22570GO:0008203FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041cholesterol metabolic process
159[]Q8IY47GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-8GO_REF:0000041protein ubiquitination
160[]O60513GO:0006486FalseTrue[rdfs:subClassOf, BFO:0000050]-8GO_REF:0000041protein glycosylation
161[]Q6P050GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
162[]Q86WB0GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
163[]Q13946GO:0006198FalseTrue[rdfs:subClassOf, BFO:0000050]-46GO_REF:0000041cAMP catabolic process
164[]Q9UDR5GO:0033512FalseTrue[rdfs:subClassOf, BFO:0000050]-25GO_REF:0000041L-lysine catabolic process to acetyl-CoA via s...
165[]Q01433GO:0032264FalseTrue[rdfs:subClassOf, BFO:0000050]-6GO_REF:0000041IMP salvage
166[]Q9H3R1GO:0030210FalseTrue[rdfs:subClassOf, BFO:0000050]-7GO_REF:0000041heparin biosynthetic process
167[]Q08499GO:0006198FalseTrue[rdfs:subClassOf, BFO:0000050]-46GO_REF:0000041cAMP catabolic process
168[]Q9UK99GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
169[]P50336GO:0006782FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041protoporphyrinogen IX biosynthetic process
170[]Q9NXK8GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
171[]Q9NV06GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-7GO_REF:0000041protein ubiquitination
172[]Q5T6F0GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
173[]Q9NPZ5GO:0006486FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein glycosylation
174[]Q6ZS86GO:0019563FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041glycerol catabolic process
175[]Q8IWU9GO:0042427FalseTrue[rdfs:subClassOf, BFO:0000050]-21GO_REF:0000041serotonin biosynthetic process
176[]Q14410GO:0019563FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041glycerol catabolic process
177[]P04818GO:0006235FalseTrue[rdfs:subClassOf, BFO:0000050]-8GO_REF:0000041dTTP biosynthetic process
178[]Q8IWR1GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
179[]O60512GO:0006486FalseTrue[rdfs:subClassOf, BFO:0000050]-10GO_REF:0000041protein glycosylation
180[]P42357GO:0019556FalseTrue[rdfs:subClassOf, BFO:0000050]-8GO_REF:0000041histidine catabolic process to glutamate and f...
181[]P42357GO:0019557FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041histidine catabolic process to glutamate and f...
182[]Q9NRD1GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
183[]Q9NYL5GO:0006707FalseTrue[rdfs:subClassOf, BFO:0000050]-13GO_REF:0000041cholesterol catabolic process
184[]O75159GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041protein ubiquitination
185[]Q9UJV3GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-7GO_REF:0000041protein ubiquitination
186[]Q9NUQ2GO:0016024FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041CDP-diacylglycerol biosynthetic process
187[]P16442GO:0006486FalseTrue[rdfs:subClassOf, BFO:0000050]-16GO_REF:0000041protein glycosylation
188[]Q9UBQ6GO:0015012FalseTrue[rdfs:subClassOf, BFO:0000050]-16GO_REF:0000041heparan sulfate proteoglycan biosynthetic process
189[]P33260GO:0042572FalseTrue[rdfs:subClassOf, BFO:0000050]-4GO_REF:0000041retinol metabolic process
190[]P61962GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-13GO_REF:0000041protein ubiquitination
191[]Q9UHE5GO:0006749FalseTrue[rdfs:subClassOf, BFO:0000050]-1GO_REF:0000041glutathione metabolic process
192[]Q86Y38GO:0030206FalseTrue[rdfs:subClassOf, BFO:0000050]-3GO_REF:0000041chondroitin sulfate biosynthetic process
193[]P08684GO:0008203FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041cholesterol metabolic process
194[]Q8WXK3GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
195[]Q92935GO:0006486FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein glycosylation
196[]Q9BSL1GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-13GO_REF:0000041protein ubiquitination
197[]Q8N806GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
198[]Q6PID8GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
199[]O14512GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041protein ubiquitination
200[]P54886GO:0055129FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041L-proline biosynthetic process
201[]Q9NPI5GO:0009435FalseTrue[rdfs:subClassOf, BFO:0000050]-18GO_REF:0000041NAD biosynthetic process
202[]Q9HB03GO:0006636FalseTrue[rdfs:subClassOf, BFO:0000050]-1GO_REF:0000041unsaturated fatty acid biosynthetic process
203[]Q7Z6M2GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
204[]Q8NC69GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
205[]Q6ZNI0GO:0006486FalseTrue[rdfs:subClassOf, BFO:0000050]-21GO_REF:0000041protein glycosylation
206[]P20711GO:0042416FalseTrue[rdfs:subClassOf, BFO:0000050]-6GO_REF:0000041dopamine biosynthetic process
207[]Q8TBE9GO:0006045FalseTrue[rdfs:subClassOf, BFO:0000050]-4GO_REF:0000041N-acetylglucosamine biosynthetic process
208[]Q66K89GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-7GO_REF:0000041protein ubiquitination
209[]Q9BZQ6GO:0006486FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041protein glycosylation
210[]Q495W5GO:0006486FalseTrue[rdfs:subClassOf, BFO:0000050]-18GO_REF:0000041protein glycosylation
211[]O95954GO:0019556FalseTrue[rdfs:subClassOf, BFO:0000050]-24GO_REF:0000041histidine catabolic process to glutamate and f...
212[]O95954GO:0019557FalseTrue[rdfs:subClassOf, BFO:0000050]-25GO_REF:0000041histidine catabolic process to glutamate and f...
213[]P11712GO:0008203FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041cholesterol metabolic process
214[]Q6P3W2GO:0017183FalseTrue[rdfs:subClassOf, BFO:0000050]-33GO_REF:0000041peptidyl-diphthamide biosynthetic process from...
215[]Q8WXJ9GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
216[]Q7L622GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
217[]Q8N4N3GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
218[]O60218GO:0042572FalseTrue[rdfs:subClassOf, BFO:0000050]0GO_REF:0000041retinol metabolic process
219[]Q12829GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
220[]Q9NWZ5GO:0044206FalseTrue[rdfs:subClassOf, BFO:0000050]-4GO_REF:0000041UMP salvage
221[]Q9NWZ5GO:0044211FalseTrue[rdfs:subClassOf, BFO:0000050]-14GO_REF:0000041CTP salvage
222[]P05091GO:0006068FalseTrue[rdfs:subClassOf, BFO:0000050]-7GO_REF:0000041ethanol catabolic process
223[]Q13825GO:0006552FalseTrue[rdfs:subClassOf, BFO:0000050]-11GO_REF:0000041leucine catabolic process
224[]Q6PJ21GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
225[]Q93088GO:0006579FalseTrue[rdfs:subClassOf, BFO:0000050]-7GO_REF:0000041amino-acid betaine catabolic process
226[]P24298GO:0042853FalseTrue[rdfs:subClassOf, BFO:0000050]-26GO_REF:0000041L-alanine catabolic process
227[]Q96L58GO:0030206FalseTrue[rdfs:subClassOf, BFO:0000050]-10GO_REF:0000041chondroitin sulfate biosynthetic process
228[]Q96L58GO:0015012FalseTrue[rdfs:subClassOf, BFO:0000050]-6GO_REF:0000041heparan sulfate proteoglycan biosynthetic process
229[]Q8N5D0GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041protein ubiquitination
230[]Q96JK2GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
231[]Q9HBI6GO:0031408FalseTrue[rdfs:subClassOf, BFO:0000050]-8GO_REF:0000041oxylipin biosynthetic process
232[]Q5T4S7GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
233[]P27815GO:0006198FalseTrue[rdfs:subClassOf, BFO:0000050]-46GO_REF:0000041cAMP catabolic process
234[]Q8NE62GO:0019285FalseTrue[rdfs:subClassOf, BFO:0000050]-15GO_REF:0000041glycine betaine biosynthetic process from choline
235[]Q03393GO:0006729FalseTrue[rdfs:subClassOf, BFO:0000050]-25GO_REF:0000041tetrahydrobiopterin biosynthetic process
236[]Q96JP0GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
237[]Q8NEA9GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
238[]Q9NWX5GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
239[]Q6JEL2GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
240[]Q92947GO:0006568FalseTrue[rdfs:subClassOf, BFO:0000050]-8GO_REF:0000041tryptophan metabolic process
241[]Q53H12GO:0046486FalseTrue[rdfs:subClassOf, BFO:0000050]-1GO_REF:0000041glycerolipid metabolic process
242[]Q5TAQ9GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-13GO_REF:0000041protein ubiquitination
243[]Q05516GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-7GO_REF:0000041protein ubiquitination
244[]Q9UK73GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
245[]Q96L50GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-13GO_REF:0000041protein ubiquitination
246[]P30837GO:0006068FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041ethanol catabolic process
247[]Q9UKU7GO:0006574FalseTrue[rdfs:subClassOf, BFO:0000050]-23GO_REF:0000041valine catabolic process
248[]Q9UJM8GO:0006545FalseTrue[rdfs:subClassOf, BFO:0000050]-17GO_REF:0000041glycine biosynthetic process
249[]Q5VXH4GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
250[]Q6IQ16GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
251[]Q9Y2T3GO:0006147FalseTrue[rdfs:subClassOf, BFO:0000050]-3GO_REF:0000041guanine catabolic process
252[]Q9HCL2GO:0016024FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041CDP-diacylglycerol biosynthetic process
253[]A5PLL7GO:0006631FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041fatty acid metabolic process
254[]Q15345GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-13GO_REF:0000041protein ubiquitination
255[]P17812GO:0044210FalseTrue[rdfs:subClassOf, BFO:0000050]-1GO_REF:0000041'de novo' CTP biosynthetic process
256[]Q9Y223GO:0006045FalseTrue[rdfs:subClassOf, BFO:0000050]-8GO_REF:0000041N-acetylglucosamine biosynthetic process
257[]P10635GO:0008203FalseTrue[rdfs:subClassOf, BFO:0000050]-3GO_REF:0000041cholesterol metabolic process
258[]Q07343GO:0006198FalseTrue[rdfs:subClassOf, BFO:0000050]-46GO_REF:0000041cAMP catabolic process
259[]P00439GO:0006559FalseTrue[rdfs:subClassOf, BFO:0000050]-16GO_REF:0000041L-phenylalanine catabolic process
260[]Q9H9P5GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-13GO_REF:0000041protein ubiquitination
261[]P32754GO:0006559FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041L-phenylalanine catabolic process
262[]P46019GO:0005977FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041glycogen metabolic process
263[]O94766GO:0006486FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein glycosylation
264[]Q4G163GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
265[]P31350GO:0006260FalseTrue[rdfs:subClassOf, BFO:0000050]-4GO_REF:0000041DNA replication
266[]Q9Y5Q0GO:0006665FalseTrue[rdfs:subClassOf, BFO:0000050]-4GO_REF:0000041sphingolipid metabolic process
267[]O60658GO:0006198FalseTrue[rdfs:subClassOf, BFO:0000050]-46GO_REF:0000041cAMP catabolic process
268[]Q9Y2U9GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
269[]Q53GQ0GO:0006703FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041estrogen biosynthetic process
270[]Q53GQ0GO:0006633FalseTrue[rdfs:subClassOf, BFO:0000050]-11GO_REF:0000041fatty acid biosynthetic process
271[]C9JR72GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
272[]Q9H765GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
273[]Q6NUI2GO:0016024FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041CDP-diacylglycerol biosynthetic process
274[]Q08493GO:0006198FalseTrue[rdfs:subClassOf, BFO:0000050]-46GO_REF:0000041cAMP catabolic process
275[]Q08477GO:0019369FalseTrue[rdfs:subClassOf, BFO:0000050]-3GO_REF:0000041arachidonic acid metabolic process
276[]O95045GO:0044206FalseTrue[rdfs:subClassOf, BFO:0000050]-35GO_REF:0000041UMP salvage
277[]O94788GO:0042572FalseTrue[rdfs:subClassOf, BFO:0000050]-4GO_REF:0000041retinol metabolic process
278[]Q8WWF5GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
279[]P52848GO:0030210FalseTrue[rdfs:subClassOf, BFO:0000050]-7GO_REF:0000041heparin biosynthetic process
280[]Q8N9L9GO:0006633FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041fatty acid biosynthetic process
281[]Q92523GO:0006635FalseTrue[rdfs:subClassOf, BFO:0000050]-14GO_REF:0000041fatty acid beta-oxidation
282[]A8MQ27GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
283[]Q86UL3GO:0016024FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041CDP-diacylglycerol biosynthetic process
284[]Q8NFW8GO:0006054FalseTrue[rdfs:subClassOf, BFO:0000050]-15GO_REF:0000041N-acetylneuraminate metabolic process
285[]Q9C026GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
286[]Q9Y233GO:0046069FalseTrue[rdfs:subClassOf, BFO:0000050]-46GO_REF:0000041cGMP catabolic process
287[]Q9Y233GO:0006198FalseTrue[rdfs:subClassOf, BFO:0000050]-46GO_REF:0000041cAMP catabolic process
288[]Q86YJ5GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-13GO_REF:0000041protein ubiquitination
289[]Q9NRZ5GO:0016024FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041CDP-diacylglycerol biosynthetic process
290[]Q13191GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-3GO_REF:0000041protein ubiquitination
291[]P43353GO:0006068FalseTrue[rdfs:subClassOf, BFO:0000050]-7GO_REF:0000041ethanol catabolic process
292[]P46020GO:0005977FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041glycogen metabolic process
293[]P0DUQ2GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
294[]Q6YP21GO:0097053FalseTrue[rdfs:subClassOf, BFO:0000050]-13GO_REF:0000041L-kynurenine catabolic process
295[]Q93100GO:0005977FalseTrue[rdfs:subClassOf, BFO:0000050]-6GO_REF:0000041glycogen metabolic process
296[]Q58WW2GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-7GO_REF:0000041protein ubiquitination
297[]Q9P2E8GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-13GO_REF:0000041protein ubiquitination
298[]Q6ZVZ8GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
299[]Q8NDV1GO:0006486FalseTrue[rdfs:subClassOf, BFO:0000050]-6GO_REF:0000041protein glycosylation
300[]Q96G25GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-7GO_REF:0000041protein ubiquitination
301[]P05177GO:0008203FalseTrue[rdfs:subClassOf, BFO:0000050]-3GO_REF:0000041cholesterol metabolic process
302[]Q9H832GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
303[]Q13085GO:2001295FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041malonyl-CoA biosynthetic process
304[]Q96K19GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-13GO_REF:0000041protein ubiquitination
305[]Q9NPC3GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-7GO_REF:0000041protein ubiquitination
306[]Q5T447GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
307[]O95263GO:0006198FalseTrue[rdfs:subClassOf, BFO:0000050]-46GO_REF:0000041cAMP catabolic process
308[]O60476GO:0006486FalseTrue[rdfs:subClassOf, BFO:0000050]-9GO_REF:0000041protein glycosylation
309[]O95864GO:0006636FalseTrue[rdfs:subClassOf, BFO:0000050]-10GO_REF:0000041unsaturated fatty acid biosynthetic process
310[]Q9UBX8GO:0006486FalseTrue[rdfs:subClassOf, BFO:0000050]-10GO_REF:0000041protein glycosylation
311[]P30793GO:0035998FalseTrue[rdfs:subClassOf, BFO:0000050]-6GO_REF:00000417,8-dihydroneopterin 3'-triphosphate biosynthe...
312[]P29218GO:0006021FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041inositol biosynthetic process
313[]Q9UL01GO:0030206FalseTrue[rdfs:subClassOf, BFO:0000050]-2GO_REF:0000041chondroitin sulfate biosynthetic process
314[]Q9UL01GO:0015012FalseTrue[rdfs:subClassOf, BFO:0000050]-1GO_REF:0000041heparan sulfate proteoglycan biosynthetic process
315[]O14544GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
316[]Q9NYP7GO:0006636FalseTrue[rdfs:subClassOf, BFO:0000050]-1GO_REF:0000041unsaturated fatty acid biosynthetic process
317[]Q16773GO:0097053FalseTrue[rdfs:subClassOf, BFO:0000050]-13GO_REF:0000041L-kynurenine catabolic process
318[]P49419GO:0019285FalseTrue[rdfs:subClassOf, BFO:0000050]-13GO_REF:0000041glycine betaine biosynthetic process from choline
319[]Q8NA82GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-13GO_REF:0000041protein ubiquitination
320[]P48637GO:0006750FalseTrue[rdfs:subClassOf, BFO:0000050]0GO_REF:0000041glutathione biosynthetic process
321[]P41226GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-1GO_REF:0000041protein ubiquitination
322[]Q8WXI3GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041protein ubiquitination
323[]Q8NC42GO:0016567FalseTrue[rdfs:subClassOf, BFO:0000050]-5GO_REF:0000041protein ubiquitination
\n", "
" ], "text/plain": [ " publications subject old_object old_object_obsolete is_deletion \\\n", "0 [] Q53EU6 GO:0016024 False True \n", "1 [] Q5VZY2 GO:0006644 False True \n", "2 [] P10632 GO:0042572 False True \n", "3 [] Q9NXB9 GO:0006636 False True \n", "4 [] Q969V5 GO:0016925 False True \n", "5 [] Q9P2W7 GO:0006486 False True \n", "6 [] A6NK59 GO:0016567 False True \n", "7 [] Q9H1B5 GO:0030206 False True \n", "8 [] Q693B1 GO:0016567 False True \n", "9 [] O60927 GO:0016567 False True \n", "10 [] Q8WV16 GO:0016567 False True \n", "11 [] Q9UK23 GO:0006486 False True \n", "12 [] Q9HAY6 GO:0042572 False True \n", "13 [] P30038 GO:0010133 False True \n", "14 [] P20815 GO:0042572 False True \n", "15 [] P11172 GO:0044205 False True \n", "16 [] Q9H920 GO:0016567 False True \n", "17 [] Q8N9I9 GO:0016567 False True \n", "18 [] Q8TD30 GO:0042853 False True \n", "19 [] P43304 GO:0019563 False True \n", "20 [] Q8WXH6 GO:0016567 False True \n", "21 [] Q9NQC1 GO:0016567 False True \n", "22 [] Q15370 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biosynthetic process \n", "1 phospholipid metabolic process \n", "2 retinol metabolic process \n", "3 unsaturated fatty acid biosynthetic process \n", "4 protein sumoylation \n", "5 protein glycosylation \n", "6 protein ubiquitination \n", "7 chondroitin sulfate biosynthetic process \n", "8 protein ubiquitination \n", "9 protein ubiquitination \n", "10 protein ubiquitination \n", "11 protein glycosylation \n", "12 retinol metabolic process \n", "13 proline catabolic process to glutamate \n", "14 retinol metabolic process \n", "15 'de novo' UMP biosynthetic process \n", "16 protein ubiquitination \n", "17 protein ubiquitination \n", "18 L-alanine catabolic process \n", "19 glycerol catabolic process \n", "20 protein ubiquitination \n", "21 protein ubiquitination \n", "22 protein ubiquitination \n", "23 protoporphyrinogen IX biosynthetic process \n", "24 L-asparagine biosynthetic process \n", "25 L-lysine catabolic process to acetyl-CoA via s... \n", "26 protoporphyrinogen IX biosynthetic process \n", "27 retinol metabolic process \n", "28 spermine catabolic process \n", "29 protein ubiquitination \n", "30 protein ubiquitination \n", "31 protein glycosylation \n", "32 protein ubiquitination \n", "33 protein sumoylation \n", "34 amino-acid betaine catabolic process \n", "35 protein ubiquitination \n", "36 ethanol catabolic process \n", "37 protein ubiquitination \n", "38 fatty acid beta-oxidation \n", "39 protoporphyrinogen IX biosynthetic process \n", "40 'de novo' IMP biosynthetic process \n", "41 protein ubiquitination \n", "42 protein ubiquitination \n", "43 phospholipid metabolic process \n", "44 protoporphyrinogen IX biosynthetic process \n", "45 glycerol catabolic process \n", "46 protein ubiquitination \n", "47 protein ubiquitination \n", "48 retinol metabolic process \n", "49 deoxyribose phosphate catabolic process \n", "50 L-proline biosynthetic process \n", "51 estrogen biosynthetic process \n", "52 retinol metabolic process \n", "53 retinol metabolic process \n", "54 protein ubiquitination \n", "55 protein ubiquitination \n", "56 protein ubiquitination \n", "57 fatty acid biosynthetic process \n", "58 protein ubiquitination \n", "59 histidine catabolic process to glutamate and f... \n", "60 histidine catabolic process to glutamate and f... \n", "61 CDP-diacylglycerol biosynthetic process \n", "62 protein ubiquitination \n", "63 protein ubiquitination \n", "64 retinol metabolic process \n", "65 fatty acid metabolic process \n", "66 protein ubiquitination \n", "67 protein ubiquitination \n", "68 AMP salvage \n", "69 cAMP catabolic process \n", "70 gluconeogenesis \n", "71 'de novo' UMP biosynthetic process \n", "72 protein ubiquitination \n", "73 CDP-diacylglycerol biosynthetic process \n", "74 protein ubiquitination \n", "75 protein glycosylation \n", "76 protein ubiquitination \n", "77 carnitine biosynthetic process \n", "78 epinephrine biosynthetic process \n", "79 protein ubiquitination \n", "80 fatty acid beta-oxidation \n", "81 protein ubiquitination \n", "82 protoporphyrinogen IX biosynthetic process \n", "83 protein glycosylation \n", "84 protein ubiquitination \n", "85 proteasome-mediated ubiquitin-dependent protei... \n", "86 fatty acid beta-oxidation \n", "87 protein ubiquitination \n", "88 protein ubiquitination \n", "89 dimethylallyl diphosphate biosynthetic process \n", "90 geranyl diphosphate biosynthetic process \n", "91 protein sumoylation \n", "92 protein ubiquitination \n", "93 triglyceride catabolic process \n", "94 protein ubiquitination \n", "95 protein ubiquitination \n", "96 protein glycosylation \n", "97 cGMP catabolic process \n", "98 putrescine catabolic process \n", "99 CDP-diacylglycerol biosynthetic process \n", "100 NAD biosynthetic process \n", "101 protein ubiquitination \n", "102 fatty acid metabolic process \n", "103 protein ubiquitination \n", "104 geranyl diphosphate biosynthetic process \n", "105 geranylgeranyl diphosphate biosynthetic process \n", "106 farnesyl diphosphate biosynthetic process \n", "107 protein ubiquitination \n", "108 protein ubiquitination \n", "109 urea cycle \n", "110 IMP salvage \n", "111 protein ubiquitination \n", "112 protein ubiquitination \n", "113 heparin biosynthetic process \n", "114 cholesterol metabolic process \n", "115 'de novo' CTP biosynthetic process \n", "116 protein ubiquitination \n", "117 IMP salvage \n", "118 fatty acid metabolic process \n", "119 protein ubiquitination \n", "120 'de novo' IMP biosynthetic process \n", "121 UMP salvage \n", "122 L-kynurenine catabolic process \n", "123 protein ubiquitination \n", "124 protein ubiquitination \n", "125 oxidative phosphorylation \n", "126 GPI anchor biosynthetic process \n", "127 dimethylallyl diphosphate biosynthetic process \n", "128 oxylipin biosynthetic process \n", "129 protein ubiquitination \n", "130 urea cycle \n", "131 L-lysine catabolic process to acetyl-CoA via s... \n", "132 protein ubiquitination \n", "133 protein glycosylation \n", "134 protoporphyrinogen IX biosynthetic process \n", "135 unsaturated fatty acid biosynthetic process \n", "136 L-kynurenine catabolic process \n", "137 protein ubiquitination \n", "138 protein ubiquitination \n", "139 CDP-diacylglycerol biosynthetic process \n", "140 protein ubiquitination \n", "141 protein glycosylation \n", "142 testosterone biosynthetic process \n", "143 malonyl-CoA biosynthetic process \n", "144 protein ubiquitination \n", "145 protein ubiquitination \n", "146 glycerol catabolic process \n", "147 retinol metabolic process \n", "148 protein glycosylation \n", "149 heparin biosynthetic process \n", "150 inositol biosynthetic process \n", "151 D-ribose catabolic process \n", "152 beta-alanine biosynthetic process \n", "153 protein ubiquitination \n", "154 histidine catabolic process to glutamate and f... \n", "155 histidine catabolic process to glutamate and f... \n", "156 urea cycle \n", "157 protein ubiquitination \n", "158 cholesterol metabolic process \n", "159 protein ubiquitination \n", "160 protein glycosylation \n", "161 protein ubiquitination \n", "162 protein ubiquitination \n", "163 cAMP catabolic process \n", "164 L-lysine catabolic process to acetyl-CoA via s... \n", "165 IMP salvage \n", "166 heparin biosynthetic process \n", "167 cAMP catabolic process \n", "168 protein ubiquitination \n", "169 protoporphyrinogen IX biosynthetic process \n", "170 protein ubiquitination \n", "171 protein ubiquitination \n", "172 protein ubiquitination \n", "173 protein glycosylation \n", "174 glycerol catabolic process \n", "175 serotonin biosynthetic process \n", "176 glycerol catabolic process \n", "177 dTTP biosynthetic process \n", "178 protein ubiquitination \n", "179 protein glycosylation \n", "180 histidine catabolic process to glutamate and f... \n", "181 histidine catabolic process to glutamate and f... \n", "182 protein ubiquitination \n", "183 cholesterol catabolic process \n", "184 protein ubiquitination \n", "185 protein ubiquitination \n", "186 CDP-diacylglycerol biosynthetic process \n", "187 protein glycosylation \n", "188 heparan sulfate proteoglycan biosynthetic process \n", "189 retinol metabolic process \n", "190 protein ubiquitination \n", "191 glutathione metabolic process \n", "192 chondroitin sulfate biosynthetic process \n", "193 cholesterol metabolic process \n", "194 protein ubiquitination \n", "195 protein glycosylation \n", "196 protein ubiquitination \n", "197 protein ubiquitination \n", "198 protein ubiquitination \n", "199 protein ubiquitination \n", "200 L-proline biosynthetic process \n", "201 NAD biosynthetic process \n", "202 unsaturated fatty acid biosynthetic process \n", "203 protein ubiquitination \n", "204 protein ubiquitination \n", "205 protein glycosylation \n", "206 dopamine biosynthetic process \n", "207 N-acetylglucosamine biosynthetic process \n", "208 protein ubiquitination \n", "209 protein glycosylation \n", "210 protein glycosylation \n", "211 histidine catabolic process to glutamate and f... \n", "212 histidine catabolic process to glutamate and f... \n", "213 cholesterol metabolic process \n", "214 peptidyl-diphthamide biosynthetic process from... \n", "215 protein ubiquitination \n", "216 protein ubiquitination \n", "217 protein ubiquitination \n", "218 retinol metabolic process \n", "219 protein ubiquitination \n", "220 UMP salvage \n", "221 CTP salvage \n", "222 ethanol catabolic process \n", "223 leucine catabolic process \n", "224 protein ubiquitination \n", "225 amino-acid betaine catabolic process \n", "226 L-alanine catabolic process \n", "227 chondroitin sulfate biosynthetic process \n", "228 heparan sulfate proteoglycan biosynthetic process \n", "229 protein ubiquitination \n", "230 protein ubiquitination \n", "231 oxylipin biosynthetic process \n", "232 protein ubiquitination \n", "233 cAMP catabolic process \n", "234 glycine betaine biosynthetic process from choline \n", "235 tetrahydrobiopterin biosynthetic process \n", "236 protein ubiquitination \n", "237 protein ubiquitination \n", "238 protein ubiquitination \n", "239 protein ubiquitination \n", "240 tryptophan metabolic process \n", "241 glycerolipid metabolic process \n", "242 protein ubiquitination \n", "243 protein ubiquitination \n", "244 protein ubiquitination \n", "245 protein ubiquitination \n", "246 ethanol catabolic process \n", "247 valine catabolic process \n", "248 glycine biosynthetic process \n", "249 protein ubiquitination \n", "250 protein ubiquitination \n", "251 guanine catabolic process \n", "252 CDP-diacylglycerol biosynthetic process \n", "253 fatty acid metabolic process \n", "254 protein ubiquitination \n", "255 'de novo' CTP biosynthetic process \n", "256 N-acetylglucosamine biosynthetic process \n", "257 cholesterol metabolic process \n", "258 cAMP catabolic process \n", "259 L-phenylalanine catabolic process \n", "260 protein ubiquitination \n", "261 L-phenylalanine catabolic process \n", "262 glycogen metabolic process \n", "263 protein glycosylation \n", "264 protein ubiquitination \n", "265 DNA replication \n", "266 sphingolipid metabolic process \n", "267 cAMP catabolic process \n", "268 protein ubiquitination \n", "269 estrogen biosynthetic process \n", "270 fatty acid biosynthetic process \n", "271 protein ubiquitination \n", "272 protein ubiquitination \n", "273 CDP-diacylglycerol biosynthetic process \n", "274 cAMP catabolic process \n", "275 arachidonic acid metabolic process \n", "276 UMP salvage \n", "277 retinol metabolic process \n", "278 protein ubiquitination \n", "279 heparin biosynthetic process \n", "280 fatty acid biosynthetic process \n", "281 fatty acid beta-oxidation \n", "282 protein ubiquitination \n", "283 CDP-diacylglycerol biosynthetic process \n", "284 N-acetylneuraminate metabolic process \n", "285 protein ubiquitination \n", "286 cGMP catabolic process \n", "287 cAMP catabolic process \n", "288 protein ubiquitination \n", "289 CDP-diacylglycerol biosynthetic process \n", "290 protein ubiquitination \n", "291 ethanol catabolic process \n", "292 glycogen metabolic process \n", "293 protein ubiquitination \n", "294 L-kynurenine catabolic process \n", "295 glycogen metabolic process \n", "296 protein ubiquitination \n", "297 protein ubiquitination \n", "298 protein ubiquitination \n", "299 protein glycosylation \n", "300 protein ubiquitination \n", "301 cholesterol metabolic process \n", "302 protein ubiquitination \n", "303 malonyl-CoA biosynthetic process \n", "304 protein ubiquitination \n", "305 protein ubiquitination \n", "306 protein ubiquitination \n", "307 cAMP catabolic process \n", "308 protein glycosylation \n", "309 unsaturated fatty acid biosynthetic process \n", "310 protein glycosylation \n", "311 7,8-dihydroneopterin 3'-triphosphate biosynthe... \n", "312 inositol biosynthetic process \n", "313 chondroitin sulfate biosynthetic process \n", "314 heparan sulfate proteoglycan biosynthetic process \n", "315 protein ubiquitination \n", "316 unsaturated fatty acid biosynthetic process \n", "317 L-kynurenine catabolic process \n", "318 glycine betaine biosynthetic process from choline \n", "319 protein ubiquitination \n", "320 glutathione biosynthetic process \n", "321 protein ubiquitination \n", "322 protein ubiquitination \n", "323 protein ubiquitination " ] }, "execution_count": 104, "metadata": {}, "output_type": "execute_result" } ], "source": [ "unipathway = dfs_by_ref[\"GO_REF:0000041\"]\n", "add_labels(unipathway)\n", "unipathway" ] }, { "cell_type": "code", "execution_count": 105, "id": "cae7f28e", "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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old_object_obsoleteis_deletionclosure_delta
old_objectold_object_label
GO:0046069cGMP catabolic processFalseTrue-46
GO:0006506GPI anchor biosynthetic processFalseTrue-46
GO:0006198cAMP catabolic processFalseTrue-46
GO:0033512L-lysine catabolic process to acetyl-CoA via saccharopineFalseTrue-40
GO:0044206UMP salvageFalseTrue-35
GO:0017183peptidyl-diphthamide biosynthetic process from peptidyl-histidineFalseTrue-33
GO:0006635fatty acid beta-oxidationFalseTrue-28
GO:0042853L-alanine catabolic processFalseTrue-26
GO:0019557histidine catabolic process to glutamate and formateFalseTrue-25
GO:0006729tetrahydrobiopterin biosynthetic processFalseTrue-25
GO:0019556histidine catabolic process to glutamate and formamideFalseTrue-24
GO:2001295malonyl-CoA biosynthetic processFalseTrue-24
GO:0006574valine catabolic processFalseTrue-23
GO:0097053L-kynurenine catabolic processFalseTrue-23
GO:0006486protein glycosylationFalseTrue-21
GO:0042427serotonin biosynthetic processFalseTrue-21
GO:0006636unsaturated fatty acid biosynthetic processFalseTrue-20
GO:0009435NAD biosynthetic processFalseTrue-18
GO:0006545glycine biosynthetic processFalseTrue-17
GO:0055129L-proline biosynthetic processFalseTrue-16
GO:0006559L-phenylalanine catabolic processFalseTrue-16
GO:0015012heparan sulfate proteoglycan biosynthetic processFalseTrue-16
GO:0006054N-acetylneuraminate metabolic processFalseTrue-15
GO:0019285glycine betaine biosynthetic process from cholineFalseTrue-15
GO:0019483beta-alanine biosynthetic processFalseTrue-14
GO:0044211CTP salvageFalseTrue-14
GO:0019563glycerol catabolic processFalseTrue-14
GO:0006633fatty acid biosynthetic processFalseTrue-14
GO:0016567protein ubiquitinationFalseTrue-13
GO:0006707cholesterol catabolic processFalseTrue-13
GO:0006068ethanol catabolic processFalseTrue-12
GO:0045329carnitine biosynthetic processFalseTrue-12
GO:0061370testosterone biosynthetic processFalseTrue-12
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic processFalseTrue-12
GO:0044205'de novo' UMP biosynthetic processFalseTrue-11
GO:0006552leucine catabolic processFalseTrue-11
GO:0033386geranylgeranyl diphosphate biosynthetic processFalseTrue-10
GO:0030206chondroitin sulfate biosynthetic processFalseTrue-10
GO:0033384geranyl diphosphate biosynthetic processFalseTrue-10
GO:0045337farnesyl diphosphate biosynthetic processFalseTrue-10
GO:0019303D-ribose catabolic processFalseTrue-10
GO:0042572retinol metabolic processFalseTrue-10
GO:0000050urea cycleFalseTrue-10
GO:0005977glycogen metabolic processFalseTrue-9
GO:0006119oxidative phosphorylationFalseTrue-9
GO:0006703estrogen biosynthetic processFalseTrue-9
GO:0006235dTTP biosynthetic processFalseTrue-8
GO:0009447putrescine catabolic processFalseTrue-8
GO:0006045N-acetylglucosamine biosynthetic processFalseTrue-8
GO:0006094gluconeogenesisFalseTrue-8
GO:0006568tryptophan metabolic processFalseTrue-8
GO:0031408oxylipin biosynthetic processFalseTrue-8
GO:0006579amino-acid betaine catabolic processFalseTrue-7
GO:0030210heparin biosynthetic processFalseTrue-7
GO:0006631fatty acid metabolic processFalseTrue-7
GO:0008203cholesterol metabolic processFalseTrue-6
GO:0070981L-asparagine biosynthetic processFalseTrue-6
GO:00359987,8-dihydroneopterin 3'-triphosphate biosynthetic processFalseTrue-6
GO:0042416dopamine biosynthetic processFalseTrue-6
GO:0032264IMP salvageFalseTrue-6
GO:0006021inositol biosynthetic processFalseTrue-5
GO:0010133proline catabolic process to glutamateFalseTrue-5
GO:0006260DNA replicationFalseTrue-4
GO:0006665sphingolipid metabolic processFalseTrue-4
GO:0016925protein sumoylationFalseTrue-3
GO:0019369arachidonic acid metabolic processFalseTrue-3
GO:0006189'de novo' IMP biosynthetic processFalseTrue-3
GO:0006147guanine catabolic processFalseTrue-3
GO:0019433triglyceride catabolic processFalseTrue-2
GO:0006782protoporphyrinogen IX biosynthetic processFalseTrue-2
GO:0050992dimethylallyl diphosphate biosynthetic processFalseTrue-2
GO:0046386deoxyribose phosphate catabolic processFalseTrue-2
GO:0042418epinephrine biosynthetic processFalseTrue-2
GO:0016024CDP-diacylglycerol biosynthetic processFalseTrue-2
GO:0006644phospholipid metabolic processFalseTrue-2
GO:0046208spermine catabolic processFalseTrue-2
GO:0046486glycerolipid metabolic processFalseTrue-1
GO:0006749glutathione metabolic processFalseTrue-1
GO:0044210'de novo' CTP biosynthetic processFalseTrue-1
GO:0044209AMP salvageFalseTrue-1
GO:0006750glutathione biosynthetic processFalseTrue0
\n", "
" ], "text/plain": [ " old_object_obsolete \\\n", "old_object old_object_label \n", "GO:0046069 cGMP catabolic process False \n", "GO:0006506 GPI anchor biosynthetic process False \n", "GO:0006198 cAMP catabolic process False \n", "GO:0033512 L-lysine catabolic process to acetyl-CoA via sa... False \n", "GO:0044206 UMP salvage False \n", "GO:0017183 peptidyl-diphthamide biosynthetic process from ... False \n", "GO:0006635 fatty acid beta-oxidation False \n", "GO:0042853 L-alanine catabolic process False \n", "GO:0019557 histidine catabolic process to glutamate and fo... False \n", "GO:0006729 tetrahydrobiopterin biosynthetic process False \n", "GO:0019556 histidine catabolic process to glutamate and fo... False \n", "GO:2001295 malonyl-CoA biosynthetic process False \n", "GO:0006574 valine catabolic process False \n", "GO:0097053 L-kynurenine catabolic process False \n", "GO:0006486 protein glycosylation False \n", "GO:0042427 serotonin biosynthetic process False \n", "GO:0006636 unsaturated fatty acid biosynthetic process False \n", "GO:0009435 NAD biosynthetic process False \n", "GO:0006545 glycine biosynthetic process False \n", "GO:0055129 L-proline biosynthetic process False \n", "GO:0006559 L-phenylalanine catabolic process False \n", "GO:0015012 heparan sulfate proteoglycan biosynthetic process False \n", "GO:0006054 N-acetylneuraminate metabolic process False \n", "GO:0019285 glycine betaine biosynthetic process from choline False \n", "GO:0019483 beta-alanine biosynthetic process False \n", "GO:0044211 CTP salvage False \n", "GO:0019563 glycerol catabolic process False \n", "GO:0006633 fatty acid biosynthetic process False \n", "GO:0016567 protein ubiquitination False \n", "GO:0006707 cholesterol catabolic process False \n", "GO:0006068 ethanol catabolic process False \n", "GO:0045329 carnitine biosynthetic process False \n", "GO:0061370 testosterone biosynthetic process False \n", "GO:0043161 proteasome-mediated ubiquitin-dependent protein... False \n", "GO:0044205 'de novo' UMP biosynthetic process False \n", "GO:0006552 leucine catabolic process False \n", "GO:0033386 geranylgeranyl diphosphate biosynthetic process False \n", "GO:0030206 chondroitin sulfate biosynthetic process False \n", "GO:0033384 geranyl diphosphate biosynthetic process False \n", "GO:0045337 farnesyl diphosphate biosynthetic process False \n", "GO:0019303 D-ribose catabolic process False \n", "GO:0042572 retinol metabolic process False \n", "GO:0000050 urea cycle False \n", "GO:0005977 glycogen metabolic process False \n", "GO:0006119 oxidative phosphorylation False \n", "GO:0006703 estrogen biosynthetic process False \n", "GO:0006235 dTTP biosynthetic process False \n", "GO:0009447 putrescine catabolic process False \n", "GO:0006045 N-acetylglucosamine biosynthetic process False \n", "GO:0006094 gluconeogenesis False \n", "GO:0006568 tryptophan metabolic process False \n", "GO:0031408 oxylipin biosynthetic process False \n", "GO:0006579 amino-acid betaine catabolic process False \n", "GO:0030210 heparin biosynthetic process False \n", "GO:0006631 fatty acid metabolic process False \n", "GO:0008203 cholesterol metabolic process False \n", "GO:0070981 L-asparagine biosynthetic process False \n", "GO:0035998 7,8-dihydroneopterin 3'-triphosphate biosynthet... False \n", "GO:0042416 dopamine biosynthetic process False \n", "GO:0032264 IMP salvage False \n", "GO:0006021 inositol biosynthetic process False \n", "GO:0010133 proline catabolic process to glutamate False \n", "GO:0006260 DNA replication False \n", "GO:0006665 sphingolipid metabolic process False \n", "GO:0016925 protein sumoylation False \n", "GO:0019369 arachidonic acid metabolic process False \n", "GO:0006189 'de novo' IMP biosynthetic process False \n", "GO:0006147 guanine catabolic process False \n", "GO:0019433 triglyceride catabolic process False \n", "GO:0006782 protoporphyrinogen IX biosynthetic process False \n", "GO:0050992 dimethylallyl diphosphate biosynthetic process False \n", "GO:0046386 deoxyribose phosphate catabolic process False \n", "GO:0042418 epinephrine biosynthetic process False \n", "GO:0016024 CDP-diacylglycerol biosynthetic process False \n", "GO:0006644 phospholipid metabolic process False \n", "GO:0046208 spermine catabolic process False \n", "GO:0046486 glycerolipid metabolic process False \n", "GO:0006749 glutathione metabolic process False \n", "GO:0044210 'de novo' CTP biosynthetic process False \n", "GO:0044209 AMP salvage False \n", "GO:0006750 glutathione biosynthetic process False \n", "\n", " is_deletion \\\n", "old_object old_object_label \n", "GO:0046069 cGMP catabolic process True \n", "GO:0006506 GPI anchor biosynthetic process True \n", "GO:0006198 cAMP catabolic process True \n", "GO:0033512 L-lysine catabolic process to acetyl-CoA via sa... True \n", "GO:0044206 UMP salvage True \n", "GO:0017183 peptidyl-diphthamide biosynthetic process from ... True \n", "GO:0006635 fatty acid beta-oxidation True \n", "GO:0042853 L-alanine catabolic process True \n", "GO:0019557 histidine catabolic process to glutamate and fo... True \n", "GO:0006729 tetrahydrobiopterin biosynthetic process True \n", "GO:0019556 histidine catabolic process to glutamate and fo... True \n", "GO:2001295 malonyl-CoA biosynthetic process True \n", "GO:0006574 valine catabolic process True \n", "GO:0097053 L-kynurenine catabolic process True \n", "GO:0006486 protein glycosylation True \n", "GO:0042427 serotonin biosynthetic process True \n", "GO:0006636 unsaturated fatty acid biosynthetic process True \n", "GO:0009435 NAD biosynthetic process True \n", "GO:0006545 glycine biosynthetic process True \n", "GO:0055129 L-proline biosynthetic process True \n", "GO:0006559 L-phenylalanine catabolic process True \n", "GO:0015012 heparan sulfate proteoglycan biosynthetic process True \n", "GO:0006054 N-acetylneuraminate metabolic process True \n", "GO:0019285 glycine betaine biosynthetic process from choline True \n", "GO:0019483 beta-alanine biosynthetic process True \n", "GO:0044211 CTP salvage True \n", "GO:0019563 glycerol catabolic process True \n", "GO:0006633 fatty acid biosynthetic process True \n", "GO:0016567 protein ubiquitination True \n", "GO:0006707 cholesterol catabolic process True \n", "GO:0006068 ethanol catabolic process True \n", "GO:0045329 carnitine biosynthetic process True \n", "GO:0061370 testosterone biosynthetic process True \n", "GO:0043161 proteasome-mediated ubiquitin-dependent protein... True \n", "GO:0044205 'de novo' UMP biosynthetic process True \n", "GO:0006552 leucine catabolic process True \n", "GO:0033386 geranylgeranyl diphosphate biosynthetic process True \n", "GO:0030206 chondroitin sulfate biosynthetic process True \n", "GO:0033384 geranyl diphosphate biosynthetic process True \n", "GO:0045337 farnesyl diphosphate biosynthetic process True \n", "GO:0019303 D-ribose catabolic process True \n", "GO:0042572 retinol metabolic process True \n", "GO:0000050 urea cycle True \n", "GO:0005977 glycogen metabolic process True \n", "GO:0006119 oxidative phosphorylation True \n", "GO:0006703 estrogen biosynthetic process True \n", "GO:0006235 dTTP biosynthetic process True \n", "GO:0009447 putrescine catabolic process True \n", "GO:0006045 N-acetylglucosamine biosynthetic process True \n", "GO:0006094 gluconeogenesis True \n", "GO:0006568 tryptophan metabolic process True \n", "GO:0031408 oxylipin biosynthetic process True \n", "GO:0006579 amino-acid betaine catabolic process True \n", "GO:0030210 heparin biosynthetic process True \n", "GO:0006631 fatty acid metabolic process True \n", "GO:0008203 cholesterol metabolic process True \n", "GO:0070981 L-asparagine biosynthetic process True \n", "GO:0035998 7,8-dihydroneopterin 3'-triphosphate biosynthet... True \n", "GO:0042416 dopamine biosynthetic process True \n", "GO:0032264 IMP salvage True \n", "GO:0006021 inositol biosynthetic process True \n", "GO:0010133 proline catabolic process to glutamate True \n", "GO:0006260 DNA replication True \n", "GO:0006665 sphingolipid metabolic process True \n", "GO:0016925 protein sumoylation True \n", "GO:0019369 arachidonic acid metabolic process True \n", "GO:0006189 'de novo' IMP biosynthetic process True \n", "GO:0006147 guanine catabolic process True \n", "GO:0019433 triglyceride catabolic process True \n", "GO:0006782 protoporphyrinogen IX biosynthetic process True \n", "GO:0050992 dimethylallyl diphosphate biosynthetic process True \n", "GO:0046386 deoxyribose phosphate catabolic process True \n", "GO:0042418 epinephrine biosynthetic process True \n", "GO:0016024 CDP-diacylglycerol biosynthetic process True \n", "GO:0006644 phospholipid metabolic process True \n", "GO:0046208 spermine catabolic process True \n", "GO:0046486 glycerolipid metabolic process True \n", "GO:0006749 glutathione metabolic process True \n", "GO:0044210 'de novo' CTP biosynthetic process True \n", "GO:0044209 AMP salvage True \n", "GO:0006750 glutathione biosynthetic process True \n", "\n", " closure_delta \n", "old_object old_object_label \n", "GO:0046069 cGMP catabolic process -46 \n", "GO:0006506 GPI anchor biosynthetic process -46 \n", "GO:0006198 cAMP catabolic process -46 \n", "GO:0033512 L-lysine catabolic process to acetyl-CoA via sa... -40 \n", "GO:0044206 UMP salvage -35 \n", "GO:0017183 peptidyl-diphthamide biosynthetic process from ... -33 \n", "GO:0006635 fatty acid beta-oxidation -28 \n", "GO:0042853 L-alanine catabolic process -26 \n", "GO:0019557 histidine catabolic process to glutamate and fo... -25 \n", "GO:0006729 tetrahydrobiopterin biosynthetic process -25 \n", "GO:0019556 histidine catabolic process to glutamate and fo... -24 \n", "GO:2001295 malonyl-CoA biosynthetic process -24 \n", "GO:0006574 valine catabolic process -23 \n", "GO:0097053 L-kynurenine catabolic process -23 \n", "GO:0006486 protein glycosylation -21 \n", "GO:0042427 serotonin biosynthetic process -21 \n", "GO:0006636 unsaturated fatty acid biosynthetic process -20 \n", "GO:0009435 NAD biosynthetic process -18 \n", "GO:0006545 glycine biosynthetic process -17 \n", "GO:0055129 L-proline biosynthetic process -16 \n", "GO:0006559 L-phenylalanine catabolic process -16 \n", "GO:0015012 heparan sulfate proteoglycan biosynthetic process -16 \n", "GO:0006054 N-acetylneuraminate metabolic process -15 \n", "GO:0019285 glycine betaine biosynthetic process from choline -15 \n", "GO:0019483 beta-alanine biosynthetic process -14 \n", "GO:0044211 CTP salvage -14 \n", "GO:0019563 glycerol catabolic process -14 \n", "GO:0006633 fatty acid biosynthetic process -14 \n", "GO:0016567 protein ubiquitination -13 \n", "GO:0006707 cholesterol catabolic process -13 \n", "GO:0006068 ethanol catabolic process -12 \n", "GO:0045329 carnitine biosynthetic process -12 \n", "GO:0061370 testosterone biosynthetic process -12 \n", "GO:0043161 proteasome-mediated ubiquitin-dependent protein... -12 \n", "GO:0044205 'de novo' UMP biosynthetic process -11 \n", "GO:0006552 leucine catabolic process -11 \n", "GO:0033386 geranylgeranyl diphosphate biosynthetic process -10 \n", "GO:0030206 chondroitin sulfate biosynthetic process -10 \n", "GO:0033384 geranyl diphosphate biosynthetic process -10 \n", "GO:0045337 farnesyl diphosphate biosynthetic process -10 \n", "GO:0019303 D-ribose catabolic process -10 \n", "GO:0042572 retinol metabolic process -10 \n", "GO:0000050 urea cycle -10 \n", "GO:0005977 glycogen metabolic process -9 \n", "GO:0006119 oxidative phosphorylation -9 \n", "GO:0006703 estrogen biosynthetic process -9 \n", "GO:0006235 dTTP biosynthetic process -8 \n", "GO:0009447 putrescine catabolic process -8 \n", "GO:0006045 N-acetylglucosamine biosynthetic process -8 \n", "GO:0006094 gluconeogenesis -8 \n", "GO:0006568 tryptophan metabolic process -8 \n", "GO:0031408 oxylipin biosynthetic process -8 \n", "GO:0006579 amino-acid betaine catabolic process -7 \n", "GO:0030210 heparin biosynthetic process -7 \n", "GO:0006631 fatty acid metabolic process -7 \n", "GO:0008203 cholesterol metabolic process -6 \n", "GO:0070981 L-asparagine biosynthetic process -6 \n", "GO:0035998 7,8-dihydroneopterin 3'-triphosphate biosynthet... -6 \n", "GO:0042416 dopamine biosynthetic process -6 \n", "GO:0032264 IMP salvage -6 \n", "GO:0006021 inositol biosynthetic process -5 \n", "GO:0010133 proline catabolic process to glutamate -5 \n", "GO:0006260 DNA replication -4 \n", "GO:0006665 sphingolipid metabolic process -4 \n", "GO:0016925 protein sumoylation -3 \n", "GO:0019369 arachidonic acid metabolic process -3 \n", "GO:0006189 'de novo' IMP biosynthetic process -3 \n", "GO:0006147 guanine catabolic process -3 \n", "GO:0019433 triglyceride catabolic process -2 \n", "GO:0006782 protoporphyrinogen IX biosynthetic process -2 \n", "GO:0050992 dimethylallyl diphosphate biosynthetic process -2 \n", "GO:0046386 deoxyribose phosphate catabolic process -2 \n", "GO:0042418 epinephrine biosynthetic process -2 \n", "GO:0016024 CDP-diacylglycerol biosynthetic process -2 \n", "GO:0006644 phospholipid metabolic process -2 \n", "GO:0046208 spermine catabolic process -2 \n", "GO:0046486 glycerolipid metabolic process -1 \n", "GO:0006749 glutathione metabolic process -1 \n", "GO:0044210 'de novo' CTP biosynthetic process -1 \n", "GO:0044209 AMP salvage -1 \n", "GO:0006750 glutathione biosynthetic process 0 " ] }, "execution_count": 105, "metadata": {}, "output_type": "execute_result" } ], "source": [ "pd.set_option('display.max_rows', 1000)\n", "unipathway.groupby(lbl).min(numeric_only=True).sort_values(\"closure_delta\")" ] }, { "cell_type": "code", "execution_count": 108, "id": "53931130", "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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publicationssubjectold_objectold_object_obsoleteis_deletionclosure_predicatesclosure_deltamethodold_object_label
18[]Q8TD30GO:0042853FalseTrue[rdfs:subClassOf, BFO:0000050]-12GO_REF:0000041L-alanine catabolic process
226[]P24298GO:0042853FalseTrue[rdfs:subClassOf, BFO:0000050]-26GO_REF:0000041L-alanine catabolic process
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" ], "text/plain": [ " publications subject old_object old_object_obsolete is_deletion \\\n", "18 [] Q8TD30 GO:0042853 False True \n", "226 [] P24298 GO:0042853 False True \n", "\n", " closure_predicates closure_delta method \\\n", "18 [rdfs:subClassOf, BFO:0000050] -12 GO_REF:0000041 \n", "226 [rdfs:subClassOf, BFO:0000050] -26 GO_REF:0000041 \n", "\n", " old_object_label \n", "18 L-alanine catabolic process \n", "226 L-alanine catabolic process " ] }, "execution_count": 108, "metadata": {}, "output_type": "execute_result" } ], "source": [ "unipathway.query(\"old_object == 'GO:0042853'\")" ] }, { "cell_type": "markdown", "id": "c9ebaf84", "metadata": {}, "source": [ "## Difference across species" ] }, { "cell_type": "code", "execution_count": 134, "id": "257cf54f", "metadata": {}, "outputs": [], "source": [ "human = mega_df" ] }, { "cell_type": "code", "execution_count": 129, "id": "b4940f25", "metadata": {}, "outputs": [], "source": [ "def analyze_gaf(gaf_path):\n", " species_df = gaf2df(gaf_path)\n", " print(len(species_df))\n", " by_ref = {}\n", " dfs = []\n", " for goref in gorefs:\n", " print(goref)\n", " df = analyze_iea(species_df, goref)\n", " print(len(df))\n", " df['method'] = goref\n", " dfs.append(df)\n", " all_df = pd.concat(dfs)\n", " return all_df" ] }, { "cell_type": "code", "execution_count": 124, "id": "62008228", "metadata": {}, "outputs": [], "source": [ "sgd_gaf = gaf2df(\"input/sgd.gaf\")" ] }, { "cell_type": "code", "execution_count": 125, "id": "d8227348", "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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dblocal_iddb_object_symbolqualifiersontology_class_refsupporting_referencesevidence_typewith_or_fromaspectdb_object_namedb_object_synonymsdb_object_typedb_object_taxonannotation_dateassigned_byannotation_extensionsgene_product_form
0SGDS000000735GCN4involved_inGO:1990139PMID:31211995IMPNaNPbZIP transcriptional activator of amino acid b...YEL009C|AAS3|ARG9|AAS101|amino acid starvation...proteintaxon:55929220200206SGDNaNUniProtKB:P03069
1SGDS000003026RAD6contributes_toGO:0017116PMID:9287349IDANaNFUbiquitin-conjugating enzyme (E2)YGL058W|PSO8|UBC2|E2 ubiquitin-conjugating pro...proteintaxon:55929220131012SGDpart_of(GO:0097505)UniProtKB:P06104
2SGDS000001503SPT23enablesGO:0003674GO_REF:0000015NDNaNFER membrane protein involved in regulation of ...YKL020Cproteintaxon:55929220181102SGDNaNUniProtKB:P35210
3SGDS000028746FMP49located_inGO:0005739PMID:14576278HDANaNCMitochondrial protein of unknown functionYER038W-Aproteintaxon:55929220040923SGDNaNUniProtKB:A0A023PZB3
4SGDS000005730DED1enablesGO:0003724PMID:10364207IDANaNFATP-dependent DEAD-box RNA helicase with stran...YOR204W|SPP81|DEAD-box ATP-dependent RNA helic...proteintaxon:55929220090529SGDNaNUniProtKB:P06634
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121507SGDS000000871ARG56enablesGO:0003942PMID:21873635IBAPANTHER:PTN001155520|PomBase:SPAC4G9.09c|SGD:S...Fbifunctional acetylglutamate kinase/N-acetyl-g...ARG56|YER069Wproteintaxon:55929220170228GO_CentralNaNNaN
121508SGDS000003824RPA12contributes_toGO:0001054PMID:21873635IBAPANTHER:PTN000133053|SGD:S000003824FDNA-directed RNA polymerase I core subunit RPA12RPA12|RRN4|YJR063Wproteintaxon:55929220170228GO_CentralNaNNaN
121509SGDS000006377VPS4involved_inGO:0016197PMID:21873635IBAPANTHER:PTN000553912|UniProtKB:Q9UN37|PomBase:...PAAA family ATPase VPS4VPS4|VPL4|VPT10|DID6|CSC1|END13|GRD13|YPR173Cproteintaxon:55929220221008GO_CentralNaNNaN
121510SGDS000001412MCM10enablesGO:0003688PMID:21873635IBAPANTHER:PTN000335708|SGD:S000001412FNaNMCM10|DNA43|YIL150Cproteintaxon:55929220170228GO_CentralNaNNaN
121511SGDS000001776BET3is_active_inGO:0033106PMID:21873635IBAPANTHER:PTN000316141|SGD:S000001776CTRAPP complex core subunit BET3BET3|YKR068Cproteintaxon:55929220170602GO_CentralNaNNaN
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121512 rows × 17 columns

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" ], "text/plain": [ " db local_id db_object_symbol qualifiers ontology_class_ref \\\n", "0 SGD S000000735 GCN4 involved_in GO:1990139 \n", "1 SGD S000003026 RAD6 contributes_to GO:0017116 \n", "2 SGD S000001503 SPT23 enables GO:0003674 \n", "3 SGD S000028746 FMP49 located_in GO:0005739 \n", "4 SGD S000005730 DED1 enables GO:0003724 \n", "... ... ... ... ... ... \n", "121507 SGD S000000871 ARG56 enables GO:0003942 \n", "121508 SGD S000003824 RPA12 contributes_to GO:0001054 \n", "121509 SGD S000006377 VPS4 involved_in GO:0016197 \n", "121510 SGD S000001412 MCM10 enables GO:0003688 \n", "121511 SGD S000001776 BET3 is_active_in GO:0033106 \n", "\n", " supporting_references evidence_type \\\n", "0 PMID:31211995 IMP \n", "1 PMID:9287349 IDA \n", "2 GO_REF:0000015 ND \n", "3 PMID:14576278 HDA \n", "4 PMID:10364207 IDA \n", "... ... ... \n", "121507 PMID:21873635 IBA \n", "121508 PMID:21873635 IBA \n", "121509 PMID:21873635 IBA \n", "121510 PMID:21873635 IBA \n", "121511 PMID:21873635 IBA \n", "\n", " with_or_from aspect \\\n", "0 NaN P \n", "1 NaN F \n", "2 NaN F \n", "3 NaN C \n", "4 NaN F \n", "... ... ... \n", "121507 PANTHER:PTN001155520|PomBase:SPAC4G9.09c|SGD:S... F \n", "121508 PANTHER:PTN000133053|SGD:S000003824 F \n", "121509 PANTHER:PTN000553912|UniProtKB:Q9UN37|PomBase:... P \n", "121510 PANTHER:PTN000335708|SGD:S000001412 F \n", "121511 PANTHER:PTN000316141|SGD:S000001776 C \n", "\n", " db_object_name \\\n", "0 bZIP transcriptional activator of amino acid b... \n", "1 Ubiquitin-conjugating enzyme (E2) \n", "2 ER membrane protein involved in regulation of ... \n", "3 Mitochondrial protein of unknown function \n", "4 ATP-dependent DEAD-box RNA helicase with stran... \n", "... ... \n", "121507 bifunctional acetylglutamate kinase/N-acetyl-g... \n", "121508 DNA-directed RNA polymerase I core subunit RPA12 \n", "121509 AAA family ATPase VPS4 \n", "121510 NaN \n", "121511 TRAPP complex core subunit BET3 \n", "\n", " db_object_synonyms db_object_type \\\n", "0 YEL009C|AAS3|ARG9|AAS101|amino acid starvation... protein \n", "1 YGL058W|PSO8|UBC2|E2 ubiquitin-conjugating pro... protein \n", "2 YKL020C protein \n", "3 YER038W-A protein \n", "4 YOR204W|SPP81|DEAD-box ATP-dependent RNA helic... protein \n", "... ... ... \n", "121507 ARG56|YER069W protein \n", "121508 RPA12|RRN4|YJR063W protein \n", "121509 VPS4|VPL4|VPT10|DID6|CSC1|END13|GRD13|YPR173C protein \n", "121510 MCM10|DNA43|YIL150C protein \n", "121511 BET3|YKR068C protein \n", "\n", " db_object_taxon annotation_date assigned_by annotation_extensions \\\n", "0 taxon:559292 20200206 SGD NaN \n", "1 taxon:559292 20131012 SGD part_of(GO:0097505) \n", "2 taxon:559292 20181102 SGD NaN \n", "3 taxon:559292 20040923 SGD NaN \n", "4 taxon:559292 20090529 SGD NaN \n", "... ... ... ... ... \n", "121507 taxon:559292 20170228 GO_Central NaN \n", "121508 taxon:559292 20170228 GO_Central NaN \n", "121509 taxon:559292 20221008 GO_Central NaN \n", "121510 taxon:559292 20170228 GO_Central NaN \n", "121511 taxon:559292 20170602 GO_Central NaN \n", "\n", " gene_product_form \n", "0 UniProtKB:P03069 \n", "1 UniProtKB:P06104 \n", "2 UniProtKB:P35210 \n", "3 UniProtKB:A0A023PZB3 \n", "4 UniProtKB:P06634 \n", "... ... \n", "121507 NaN \n", "121508 NaN \n", "121509 NaN \n", "121510 NaN \n", "121511 NaN \n", "\n", "[121512 rows x 17 columns]" ] }, "execution_count": 125, "metadata": {}, "output_type": "execute_result" } ], "source": [ "sgd_gaf" ] }, { "cell_type": "code", "execution_count": 126, "id": "21c2099b", "metadata": {}, "outputs": [], "source": [ "sgd_foo = analyze_iea(sgd_gaf, \"GO_REF:0000002\")" ] }, { "cell_type": "code", "execution_count": 128, "id": "aa8f85b3", "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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publicationssubjectold_objectold_object_obsoleteis_deletionclosure_predicatesclosure_deltamethod
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...........................
3743[]S000005730GO:0003676FalseTrue[rdfs:subClassOf, BFO:0000050]0GO_REF:0000002
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3748 rows × 8 columns

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" ], "text/plain": [ " publications subject old_object old_object_obsolete is_deletion \\\n", "0 [] S000005069 GO:0022857 False True \n", "1 [] S000005069 GO:0055085 False True \n", "2 [] S000006233 GO:0016192 False True \n", "3 [] S000006233 GO:0030117 False True \n", "4 [] S000006233 GO:0006886 False True \n", "... ... ... ... ... ... \n", "3743 [] S000005730 GO:0003676 False True \n", "3744 [] S000001208 GO:0000398 False True \n", "3745 [] S000001208 GO:0008237 False True \n", "3746 [] S000001208 GO:0008233 False True \n", "3747 [] S000000418 GO:0030071 False True \n", "\n", " closure_predicates closure_delta method \n", "0 [rdfs:subClassOf, BFO:0000050] 0 GO_REF:0000002 \n", "1 [rdfs:subClassOf, BFO:0000050] 0 GO_REF:0000002 \n", "2 [rdfs:subClassOf, BFO:0000050] 0 GO_REF:0000002 \n", "3 [rdfs:subClassOf, BFO:0000050] 0 GO_REF:0000002 \n", "4 [rdfs:subClassOf, BFO:0000050] -1 GO_REF:0000002 \n", "... ... ... ... \n", "3743 [rdfs:subClassOf, BFO:0000050] 0 GO_REF:0000002 \n", "3744 [rdfs:subClassOf, BFO:0000050] 0 GO_REF:0000002 \n", "3745 [rdfs:subClassOf, BFO:0000050] -4 GO_REF:0000002 \n", "3746 [rdfs:subClassOf, BFO:0000050] -3 GO_REF:0000002 \n", "3747 [rdfs:subClassOf, BFO:0000050] -15 GO_REF:0000002 \n", "\n", "[3748 rows x 8 columns]" ] }, "execution_count": 128, "metadata": {}, "output_type": "execute_result" } ], "source": [ "sgd_foo[\"method\"] = \"GO_REF:0000002\"\n", "sgd_foo" ] }, { "cell_type": "code", "execution_count": 130, "id": "5c566fad", "metadata": {}, "outputs": [ { "name": "stdout", "output_type": "stream", "text": [ "121512\n", "GO_REF:0000003\n", "362\n", "GO_REF:0000044\n", "1040\n", "GO_REF:0000002\n", "3748\n", "GO_REF:0000116\n", "0\n", "GO_REF:0000117\n", "1587\n", "GO_REF:0000107\n", "0\n", "GO_REF:0000108\n", "1028\n", "GO_REF:0000041\n", "186\n", "GO_REF:0000104\n", "127\n", "GO_REF:0000043\n", "11559\n" ] } ], "source": [ "sgd = analyze_gaf(\"input/sgd.gaf\")" ] }, { "cell_type": "code", "execution_count": 131, "id": "a084569c", "metadata": {}, "outputs": [ { "data": { "text/plain": [ "pandas.core.frame.DataFrame" ] }, "execution_count": 131, "metadata": {}, "output_type": "execute_result" } ], "source": [ "type(sgd)" ] }, { "cell_type": "code", "execution_count": 132, "id": "f0da8910", "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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publicationssubjectold_objectold_object_obsoleteis_deletionclosure_predicatesclosure_deltamethod
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...........................
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19637 rows × 8 columns

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closure_delta
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is_deletionclosure_delta
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" ], "text/plain": [ " is_deletion closure_delta\n", "method \n", "GO_REF:0000002 1.0 -6.256293\n", "GO_REF:0000003 1.0 -2.435816\n", "GO_REF:0000041 1.0 -9.901235\n", "GO_REF:0000043 1.0 -5.570560\n", "GO_REF:0000044 1.0 -6.311431\n", "GO_REF:0000104 1.0 -6.020101\n", "GO_REF:0000107 1.0 -7.604500\n", "GO_REF:0000108 1.0 -0.619598\n", "GO_REF:0000116 1.0 -1.849655\n", "GO_REF:0000117 1.0 -5.905660" ] }, "execution_count": 135, "metadata": {}, "output_type": "execute_result" } ], "source": [ "human.groupby(\"method\").mean(numeric_only=True)" ] }, { "cell_type": "code", "execution_count": 136, "id": "d246c9bb", "metadata": {}, "outputs": [], "source": [ "human[\"species\"] = \"human\"\n", "sgd[\"species\"] = \"yeast\"" ] }, { "cell_type": "code", "execution_count": 138, "id": "cc3db5aa", "metadata": {}, "outputs": [ { "name": "stderr", "output_type": "stream", "text": [ "/var/folders/nc/m4tx21912kv1b8nk3zzx9plr0000gn/T/ipykernel_40496/2618427164.py:1: FutureWarning: In a future version, object-dtype columns with all-bool values will not be included in reductions with bool_only=True. Explicitly cast to bool dtype instead.\n", " all_df = pd.concat([human, sgd])\n" ] } ], "source": [ "all_df = pd.concat([human, sgd])" ] }, { "cell_type": "code", "execution_count": 140, "id": "3bd6a411", "metadata": {}, "outputs": [ { "data": { "text/html": [ "
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" ], "text/plain": [ " closure_delta\n", "species method \n", "human GO_REF:0000002 0.084092\n", " GO_REF:0000003 0.003270\n", " GO_REF:0000041 0.006826\n", " GO_REF:0000043 0.157988\n", " GO_REF:0000044 0.108322\n", " GO_REF:0000104 0.002549\n", " GO_REF:0000107 0.627103\n", " GO_REF:0000108 0.004332\n", " GO_REF:0000116 0.002853\n", " GO_REF:0000117 0.002664\n", "pombe GO_REF:0000002 0.396889\n", " GO_REF:0000003 0.010222\n", " GO_REF:0000041 0.051185\n", " GO_REF:0000043 0.399185\n", " GO_REF:0000044 0.017778\n", " GO_REF:0000104 0.052074\n", " GO_REF:0000116 0.046370\n", " GO_REF:0000117 0.026296\n", "yeast GO_REF:0000002 0.306496\n", " GO_REF:0000003 0.026889\n", " GO_REF:0000041 0.037103\n", " GO_REF:0000043 0.480404\n", " GO_REF:0000044 0.104345\n", " GO_REF:0000104 0.017449\n", " GO_REF:0000108 0.015476\n", " GO_REF:0000117 0.011839" ] }, "execution_count": 167, "metadata": {}, "output_type": "execute_result" } ], "source": [ "smry = all_df.groupby([\"species\", \"method\"]).sum(numeric_only=True) / all_df.groupby([\"species\"]).sum(numeric_only=True)\n", "smry" ] }, { "cell_type": "code", "execution_count": 168, "id": "e350695f", "metadata": {}, "outputs": [ { "data": { "text/plain": [ "" ] }, "execution_count": 168, "metadata": {}, "output_type": "execute_result" }, { "data": { "image/png": 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", "text/plain": [ "
" ] }, "metadata": {}, "output_type": "display_data" } ], "source": [ "import seaborn\n", "\n", "pivot = smry.reset_index().pivot(index=\"method\", columns=\"species\", values=\"closure_delta\")\n", "seaborn.heatmap(pivot, annot=True, fmt=\".2f\")" ] }, { "cell_type": "code", "execution_count": 159, "id": "c5beac89", "metadata": {}, "outputs": [ { "ename": "AttributeError", "evalue": "'dict' object has no attribute 'foo'", "output_type": "error", "traceback": [ "\u001B[0;31m---------------------------------------------------------------------------\u001B[0m", "\u001B[0;31mAttributeError\u001B[0m Traceback (most recent call last)", "Cell \u001B[0;32mIn[159], line 1\u001B[0m\n\u001B[0;32m----> 1\u001B[0m \u001B[43mc\u001B[49m\u001B[38;5;241;43m.\u001B[39;49m\u001B[43mMETA\u001B[49m\u001B[38;5;241;43m.\u001B[39;49m\u001B[43mfoo\u001B[49m\n", "\u001B[0;31mAttributeError\u001B[0m: 'dict' object has no attribute 'foo'" ] } ], "source": [ "c.META.foo" ] }, { "cell_type": "code", "execution_count": null, "id": "d343e78a", "metadata": {}, "outputs": [], "source": [] } ], "metadata": { "kernelspec": { "display_name": "Python 3 (ipykernel)", "language": "python", "name": "python3" }, "language_info": { "codemirror_mode": { "name": "ipython", "version": 3 }, "file_extension": ".py", "mimetype": "text/x-python", "name": "python", "nbconvert_exporter": "python", "pygments_lexer": "ipython3", "version": "3.9.5" } }, "nbformat": 4, "nbformat_minor": 5 }